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dc.contributor.authorAlbacete-Albacete, Lucas
dc.contributor.authorSanchez-Alvarez, Miguel 
dc.contributor.authordel Pozo, Miguel Angel 
dc.date.accessioned2021-10-15T07:52:37Z
dc.date.available2021-10-15T07:52:37Z
dc.date.issued2021-04
dc.identifier.citationFront Immunol. 2021; 12:671485es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/13432
dc.description.abstractECM composition and architecture are tightly regulated for tissue homeostasis. Different disorders have been associated to alterations in the levels of proteins such as collagens, fibronectin (FN) or tenascin-C (TnC). TnC emerges as a key regulator of multiple inflammatory processes, both during physiological tissue repair as well as pathological conditions ranging from tumor progression to cardiovascular disease. Importantly, our current understanding as to how TnC and other non-collagen ECM components are secreted has remained elusive. Extracellular vesicles (EVs) are small membrane-bound particles released to the extracellular space by most cell types, playing a key role in cell-cell communication. A broad range of cellular components can be transported by EVs (e.g. nucleic acids, lipids, signalling molecules and proteins). These cargoes can be transferred to target cells, potentially modulating their function. Recently, several extracellular matrix (ECM) proteins have been characterized as bona fide EV cargoes, exosomal secretion being particularly critical for TnC. EV-dependent ECM secretion might underpin diseases where ECM integrity is altered, establishing novel concepts in the field such as ECM nucleation over long distances, and highlighting novel opportunities for diagnostics and therapeutic intervention. Here, we review recent findings and standing questions on the molecular mechanisms governing EV-dependent ECM secretion and its potential relevance for disease, with a focus on TnC.es_ES
dc.description.sponsorshipThe authors acknowledge the grant support to MP from the Spanish Ministerio de Ciencia e Innovación (CSD2009-0016, SAF2014-51876-R, SAF2017-83130-R, BFU2016-81912-REDC, and IGP-SO-MINSEV1512-07-2016), Fundació La Marató de TV3 (674/C/2013 and 201936-30-31), Worldwide Cancer Research Foundation (# 15-0404), Asociación Española Contra el Cáncer (PROYE20089DELP), and Fondo Europeo de Desarrollo Regional ”Una manera de hacer Europa”. MP received funding from the European Union Horizon 2020 research and innovation program under Marie Sklodowska-Curie grant agreement no. 641639, and is member of the Tec4Bio consortium (ref. S2018/NMT4443; Actividades de I+D entre Grupos de Investigación en Tecnologías, Comunidad Autónoma de Madrid/FEDER, Spain). LA-A was supported by a Ministerio de Ciencia, Innovación y Universidades predoctoral fellowship associated with the Severo Ochoa Excellence program (ref. SVP-2013-06789). The Centro Nacional de Investigaciones Cardiovasculares Carlos III is supported by the Ministerio de Ciencia e Innovación and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505).es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Media es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleExtracellular Vesicles: An Emerging Mechanism Governing the Secretion and Biological Roles of Tenascin-C.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID33981316es_ES
dc.format.volume12es_ES
dc.format.page671485es_ES
dc.identifier.doi10.3389/fimmu.2021.671485es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España) 
dc.contributor.funderFundación La Marató TV3 
dc.contributor.funderUnión Europea. Comisión Europea. H2020 
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España) 
dc.contributor.funderFundación ProCNIC 
dc.contributor.funderAsociación Española Contra el Cáncer 
dc.contributor.funderWorldwide Cancer Research Foundation
dc.description.peerreviewedes_ES
dc.identifier.e-issn1664-3224es_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fimmu.2021.671485es_ES
dc.identifier.journalFrontiers in immunologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Señalización por Integrinases_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/641639es_ES
dc.rights.accessRightsopen accesses_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/CSD2009-0016es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/SAF2014-51876-Res_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/SAF2017-83130-Res_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/BFU2016-81912-REDCes_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/IGP-SO-MINSEV1512-07-2016es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/674/C/2013es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/201936-30-31es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PROYE20089DELPes_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/SVP-2013-06789es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES


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