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dc.contributor.author | Albacete-Albacete, Lucas | |
dc.contributor.author | Sanchez-Alvarez, Miguel | |
dc.contributor.author | del Pozo, Miguel Angel | |
dc.date.accessioned | 2021-10-15T07:52:37Z | |
dc.date.available | 2021-10-15T07:52:37Z | |
dc.date.issued | 2021-04 | |
dc.identifier.citation | Front Immunol. 2021; 12:671485 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/13432 | |
dc.description.abstract | ECM composition and architecture are tightly regulated for tissue homeostasis. Different disorders have been associated to alterations in the levels of proteins such as collagens, fibronectin (FN) or tenascin-C (TnC). TnC emerges as a key regulator of multiple inflammatory processes, both during physiological tissue repair as well as pathological conditions ranging from tumor progression to cardiovascular disease. Importantly, our current understanding as to how TnC and other non-collagen ECM components are secreted has remained elusive. Extracellular vesicles (EVs) are small membrane-bound particles released to the extracellular space by most cell types, playing a key role in cell-cell communication. A broad range of cellular components can be transported by EVs (e.g. nucleic acids, lipids, signalling molecules and proteins). These cargoes can be transferred to target cells, potentially modulating their function. Recently, several extracellular matrix (ECM) proteins have been characterized as bona fide EV cargoes, exosomal secretion being particularly critical for TnC. EV-dependent ECM secretion might underpin diseases where ECM integrity is altered, establishing novel concepts in the field such as ECM nucleation over long distances, and highlighting novel opportunities for diagnostics and therapeutic intervention. Here, we review recent findings and standing questions on the molecular mechanisms governing EV-dependent ECM secretion and its potential relevance for disease, with a focus on TnC. | es_ES |
dc.description.sponsorship | The authors acknowledge the grant support to MP from the Spanish Ministerio de Ciencia e Innovación (CSD2009-0016, SAF2014-51876-R, SAF2017-83130-R, BFU2016-81912-REDC, and IGP-SO-MINSEV1512-07-2016), Fundació La Marató de TV3 (674/C/2013 and 201936-30-31), Worldwide Cancer Research Foundation (# 15-0404), Asociación Española Contra el Cáncer (PROYE20089DELP), and Fondo Europeo de Desarrollo Regional ”Una manera de hacer Europa”. MP received funding from the European Union Horizon 2020 research and innovation program under Marie Sklodowska-Curie grant agreement no. 641639, and is member of the Tec4Bio consortium (ref. S2018/NMT4443; Actividades de I+D entre Grupos de Investigación en Tecnologías, Comunidad Autónoma de Madrid/FEDER, Spain). LA-A was supported by a Ministerio de Ciencia, Innovación y Universidades predoctoral fellowship associated with the Severo Ochoa Excellence program (ref. SVP-2013-06789). The Centro Nacional de Investigaciones Cardiovasculares Carlos III is supported by the Ministerio de Ciencia e Innovación and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Extracellular Vesicles: An Emerging Mechanism Governing the Secretion and Biological Roles of Tenascin-C. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 33981316 | es_ES |
dc.format.volume | 12 | es_ES |
dc.format.page | 671485 | es_ES |
dc.identifier.doi | 10.3389/fimmu.2021.671485 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | |
dc.contributor.funder | Fundación La Marató TV3 | |
dc.contributor.funder | Unión Europea. Comisión Europea. H2020 | |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.contributor.funder | Asociación Española Contra el Cáncer | |
dc.contributor.funder | Worldwide Cancer Research Foundation | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1664-3224 | es_ES |
dc.relation.publisherversion | https://doi.org/10.3389/fimmu.2021.671485 | es_ES |
dc.identifier.journal | Frontiers in immunology | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Señalización por Integrinas | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/641639 | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CSD2009-0016 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/SAF2014-51876-R | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/SAF2017-83130-R | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/BFU2016-81912-REDC | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/IGP-SO-MINSEV1512-07-2016 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/674/C/2013 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/201936-30-31 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PROYE20089DELP | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/SVP-2013-06789 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |