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dc.contributor.authorMartin-Cofreces, Noa B. 
dc.contributor.authorValpuesta, Jose Maria
dc.contributor.authorSanchez-Madrid, Francisco
dc.identifier.citationFront Cell Dev Biol. 2021; 9:658460es_ES
dc.description.abstractLymphocytes rearrange their shape, membrane receptors and organelles during cognate contacts with antigen-presenting cells (APCs). Activation of T cells by APCs through pMHC-TCR/CD3 interaction (peptide-major histocompatibility complex-T cell receptor/CD3 complexes) involves different steps that lead to the reorganization of the cytoskeleton and organelles and, eventually, activation of nuclear factors allowing transcription and ultimately, replication and cell division. Both the positioning of the lymphocyte centrosome in close proximity to the APC and the nucleation of a dense microtubule network beneath the plasma membrane from the centrosome support the T cell's intracellular polarity. Signaling from the TCR is facilitated by this traffic, which constitutes an important pathway for regulation of T cell activation. The coordinated enrichment upon T cell stimulation of the chaperonin CCT (chaperonin-containing tailless complex polypeptide 1; also termed TRiC) and tubulins at the centrosome area support polarized tubulin polymerization and T cell activation. The proteasome is also enriched in the centrosome of activated T cells, providing a mechanism to balance local protein synthesis and degradation. CCT assists the folding of proteins coming from de novo synthesis, therefore favoring mRNA translation. The functional role of this chaperonin in regulating cytoskeletal composition and dynamics at the immune synapse is discussed.es_ES
dc.description.sponsorshipThis work was supported bun the ALBA Synchrotron standard proposals 2015021148 and 2016021638 to NM-C and JMV. This study was supported by grants SAF2017-82886-R (to FS-M) and PID2019-105872GB-I00/AEI/10.13039/501100011033 (AEI/FEDER, UE) (to JMV) from the Spanish Ministry of Economy and Competitiveness (MINECO), grants INFLAMUNE-S2017/BMD-23671 (to FS-M) and P2018/NMT-4389 (to JMV) from the Comunidad de Madrid, ERC-2011-AdG 294340-GENTRIS (to FS-M), a 2019 grant from the Ramón Areces Foundation “Ciencias de la Vida y la Salud” and a 2018 grant from Ayudas Fundación BBVA a Equipos de Investigación Científica (to FS-M) and grants PRB3 (IPT17/0019—ISCIII-SGEFI/ERDF), and “La Caixa” Banking Foundation (HR17-00016 to FS-M). CIBER Cardiovascular (Fondo de Investigación Sanitaria del Instituto de Salud Carlos III and co-funding by Fondo Europeo de Desarrollo Regional FEDER). The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC Foundation. The Centro Nacional de Biotecnología (CNB) was a Severo Ochoa Center of Excellence (MINECO award SEV 2017-0712). Funding agencies have not intervened in the design of the studies, with no copyright over the study.es_ES
dc.publisherFrontiers Media es_ES
dc.titleFolding for the Immune Synapse: CCT Chaperonin and the Cytoskeleton.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderALBA Synchrotron
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.contributor.funderComunidad de Madrid (España) 
dc.contributor.funderFundación Ramón Areces 
dc.contributor.funderFundación BBVA 
dc.contributor.funderFundación ProCNIC 
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderFundación La Caixa 
dc.identifier.journalFrontiers in cell and developmental biologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Comunicación Intercelular en la Respuesta Inflamatoriaes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/ERC-2011-AdG 294340-GENTRISes_ES
dc.rights.accessRightsopen accesses_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/SEV 2017-0712es_ES

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