Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/13345
Título
Immune synapse instructs epigenomic and transcriptomic functional reprogramming in dendritic cells.
Autor(es)
Alcaraz-Serna, Ana | Bustos-Moran, Eugenio CNIC | Fernandez-Delgado, Irene CNIC | Calzada-Fraile, Diego | Torralba, Daniel CNIC | Marina-Zarate, Ester CNIC | Lorenzo-Vivas, Erika | Vazquez, Enrique | Barreto de Alburquerque, Juliana | Ruef, Nora | Gomez, Manuel J CNIC | Sanchez-Cabo, Fatima CNIC | Dopazo, Ana CNIC | Stein, Jens V | Ramiro, Almudena R CNIC | Sanchez-Madrid, Francisco CNIC
Fecha de publicación
2021-02
Cita
Sci Adv. 2021; 7(6):eabb9965
Idioma
Inglés
Tipo de documento
journal article
Resumen
Understanding the fate of dendritic cells (DCs) after productive immune synapses (postsynaptic DCs) with T cells during antigen presentation has been largely neglected in favor of deciphering the nuances of T cell activation and memory generation. Here, we describe that postsynaptic DCs switch their transcriptomic signature, correlating with epigenomic changes including DNA accessibility and histone methylation. We focus on the chemokine receptor Ccr7 as a proof-of-concept gene that is increased in postsynaptic DCs. Consistent with our epigenomic observations, postsynaptic DCs migrate more efficiently toward CCL19 in vitro and display enhanced homing to draining lymph nodes in vivo. This work describes a previously unknown DC population whose transcriptomics, epigenomics, and migratory capacity change in response to their cognate contact with T cells.
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DOI
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