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dc.contributor.authorSreenivasan, Krishnamoorthy
dc.contributor.authorRodríguez-delaRosa, Alejandra
dc.contributor.authorKim, Johnny
dc.contributor.authorMesquita, Diana
dc.contributor.authorSegalés, Jessica
dc.contributor.authorGomez-del Arco, Pablo 
dc.contributor.authorEspejo, Isabel
dc.contributor.authorIanni, Alessandro
dc.contributor.authorDi Croce, Luciano
dc.contributor.authorRelaix, Frederic
dc.contributor.authorRedondo, Juan Miguel 
dc.contributor.authorBraun, Thomas
dc.contributor.authorSerrano, Antonio L
dc.contributor.authorPerdiguero, Eusebio
dc.contributor.authorMuñoz-Cánoves, Pura
dc.date.accessioned2021-09-01T18:42:10Z
dc.date.available2021-09-01T18:42:10Z
dc.date.issued2021-08-16
dc.identifier.citationStem Cell Reports . 2021;S2213-6711(21)00388-X.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/13342
dc.description.abstractRegeneration of skeletal muscle requires resident stem cells called satellite cells. Here, we report that the chromatin remodeler CHD4, a member of the nucleosome remodeling and deacetylase (NuRD) repressive complex, is essential for the expansion and regenerative functions of satellite cells. We show that conditional deletion of the Chd4 gene in satellite cells results in failure to regenerate muscle after injury. This defect is principally associated with increased stem cell plasticity and lineage infidelity during the expansion of satellite cells, caused by de-repression of non-muscle-cell lineage genes in the absence of Chd4. Thus, CHD4 ensures that a transcriptional program that safeguards satellite cell identity during muscle regeneration is maintained. Given the therapeutic potential of muscle stem cells in diverse neuromuscular pathologies, CHD4 constitutes an attractive target for satellite cell-based therapies.es_ES
dc.description.sponsorshipThe authors acknowledge funding from MINECO-Spain (grant no. RTI2018-096068), ERC-AdG-741966, LaCaixa-HEALTH- HR17-00040, MWRF, MDA, UPGRADE-H2020-825825, AFM, and DPP-Spain to P.M.C. P.G.-d.A. was supported by MINECO-Spain (grant no. SAF2016-77816-P); French ANR Labex REVIVE (grant no. ANR-10-LABX-73) to F.R. A.R. was supported by a DCEXS- UPF, BIST Fellowship. Fundacio ́ la Marato ́ de TV3 supported A.L.S. (grant no. 202033) and P.M.C. (grant no. 202021) and the Marı ́a-de-Maeztu-Program for Units of Excellence to UPF (grant no. MDM-2014-0370) and the Severo-Ochoa-Program for Centers of Excellence to CNIC (grant no. SEV-2015-0505).es_ES
dc.language.isoenges_ES
dc.publisherCell Press es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChd4es_ES
dc.subjectNuRDes_ES
dc.subjectLineage maintenancees_ES
dc.subjectMuscle stem celles_ES
dc.subjectRegenerationes_ES
dc.subjectSatellite cellses_ES
dc.subjectSkeletal musclees_ES
dc.titleCHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID34450038es_ES
dc.format.volume16es_ES
dc.format.page1-10es_ES
dc.identifier.doi10.1016/j.stemcr.2021.07.022es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.contributor.funderFundación La Caixa 
dc.contributor.funderFundación La Marató TV3 
dc.contributor.funderUnión Europea 
dc.description.peerreviewedes_ES
dc.identifier.e-issn2213-6711es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.stemcr.2021.07.022es_ES
dc.identifier.journalStem Cell Reportses_ES
dc.repisalud.centroISCIII::Instituto de Investigación de Enfermedades Rarases_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/825825/EUes_ES
dc.rights.accessRightsopen accesses_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/RTI2018-096068es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/SAF2016-77816-Pes_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 Internacional