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dc.contributor.author | Sreenivasan, Krishnamoorthy | |
dc.contributor.author | Rodríguez-delaRosa, Alejandra | |
dc.contributor.author | Kim, Johnny | |
dc.contributor.author | Mesquita, Diana | |
dc.contributor.author | Segalés, Jessica | |
dc.contributor.author | Gomez-del Arco, Pablo | |
dc.contributor.author | Espejo, Isabel | |
dc.contributor.author | Ianni, Alessandro | |
dc.contributor.author | Di Croce, Luciano | |
dc.contributor.author | Relaix, Frederic | |
dc.contributor.author | Redondo, Juan Miguel | |
dc.contributor.author | Braun, Thomas | |
dc.contributor.author | Serrano, Antonio L | |
dc.contributor.author | Perdiguero, Eusebio | |
dc.contributor.author | Muñoz-Cánoves, Pura | |
dc.date.accessioned | 2021-09-01T18:42:10Z | |
dc.date.available | 2021-09-01T18:42:10Z | |
dc.date.issued | 2021-08-16 | |
dc.identifier.citation | Stem Cell Reports . 2021;S2213-6711(21)00388-X. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/13342 | |
dc.description.abstract | Regeneration of skeletal muscle requires resident stem cells called satellite cells. Here, we report that the chromatin remodeler CHD4, a member of the nucleosome remodeling and deacetylase (NuRD) repressive complex, is essential for the expansion and regenerative functions of satellite cells. We show that conditional deletion of the Chd4 gene in satellite cells results in failure to regenerate muscle after injury. This defect is principally associated with increased stem cell plasticity and lineage infidelity during the expansion of satellite cells, caused by de-repression of non-muscle-cell lineage genes in the absence of Chd4. Thus, CHD4 ensures that a transcriptional program that safeguards satellite cell identity during muscle regeneration is maintained. Given the therapeutic potential of muscle stem cells in diverse neuromuscular pathologies, CHD4 constitutes an attractive target for satellite cell-based therapies. | es_ES |
dc.description.sponsorship | The authors acknowledge funding from MINECO-Spain (grant no. RTI2018-096068), ERC-AdG-741966, LaCaixa-HEALTH- HR17-00040, MWRF, MDA, UPGRADE-H2020-825825, AFM, and DPP-Spain to P.M.C. P.G.-d.A. was supported by MINECO-Spain (grant no. SAF2016-77816-P); French ANR Labex REVIVE (grant no. ANR-10-LABX-73) to F.R. A.R. was supported by a DCEXS- UPF, BIST Fellowship. Fundacio ́ la Marato ́ de TV3 supported A.L.S. (grant no. 202033) and P.M.C. (grant no. 202021) and the Marı ́a-de-Maeztu-Program for Units of Excellence to UPF (grant no. MDM-2014-0370) and the Severo-Ochoa-Program for Centers of Excellence to CNIC (grant no. SEV-2015-0505). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cell Press | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Chd4 | es_ES |
dc.subject | NuRD | es_ES |
dc.subject | Lineage maintenance | es_ES |
dc.subject | Muscle stem cell | es_ES |
dc.subject | Regeneration | es_ES |
dc.subject | Satellite cells | es_ES |
dc.subject | Skeletal muscle | es_ES |
dc.title | CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 34450038 | es_ES |
dc.format.volume | 16 | es_ES |
dc.format.page | 1-10 | es_ES |
dc.identifier.doi | 10.1016/j.stemcr.2021.07.022 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Fundación La Caixa | |
dc.contributor.funder | Fundación La Marató TV3 | |
dc.contributor.funder | Unión Europea | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2213-6711 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.stemcr.2021.07.022 | es_ES |
dc.identifier.journal | Stem Cell Reports | es_ES |
dc.repisalud.centro | ISCIII::Instituto de Investigación de Enfermedades Raras | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/825825/EU | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTI2018-096068 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/SAF2016-77816-P | es_ES |