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dc.contributor.author | Lozano, Encarnacion | |
dc.contributor.author | de Lucas, Maria Pilar | |
dc.contributor.author | Saez, Alberto G | |
dc.date.accessioned | 2021-06-15T19:14:31Z | |
dc.date.available | 2021-06-15T19:14:31Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Worm. 2016 Sep 21;5(4):e1238560. | es_ES |
dc.identifier.issn | 2162-4046 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/13139 | |
dc.description.abstract | The miR-58 family comprises 6 microRNAs with largely shared functions, and with an overall high expression, because one of its members, miR-58, is the most abundant microRNA in Caenorhabditis elegans. We recently found that 2 TGF-β signaling pathways, Sma/Mab and Dauer, responsible for body size and dauer formation respectively, among other phenotypes, are downregulated by the miR-58 family. Here, we further explore this family by showing that it also acts through the sta-1 3'UTR. sta-1 encodes a transcription factor, homologous to mammalian STATs, that inhibits dauer formation in association with the TGF-β Dauer pathway. We also observe that mutants with a constitutively active TGF-β Dauer pathway express higher levels of sta-1 mRNA. Our results reinforce the view of the miR-58 family and STA-1 as regulators of dauer formation in coordination with the TGF-β Dauer pathway. | es_ES |
dc.description.sponsorship | This work was funded by Fondo de Investigaciones Sanitarias (PI08/642 and PI11/120 to E.L.). E.L., M.P.L. and A.G.S. were supported by programs Ramón y Cajal, Formación de Profesorado Universitario and Fondo de Investigaciones Sanitarias, respectively, all of them from the Spanish Government. C. elegans strains were provided by CGC, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Taylor & Francis | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Dauer | es_ES |
dc.subject | TGF-β Dauer | es_ES |
dc.subject | MicroRNAs | es_ES |
dc.subject | Mir-58 | es_ES |
dc.subject | Sta-1 | es_ES |
dc.title | sta-1 is repressed by mir-58 family in Caenorhabditis elegans | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-NoComercial 4.0 Internacional | * |
dc.identifier.pubmedID | 28090395 | es_ES |
dc.format.volume | 5 | es_ES |
dc.format.number | 4 | es_ES |
dc.format.page | e1238560 | es_ES |
dc.identifier.doi | 10.1080/21624054.2016.1238560 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | NIH Office of Research Infrastructure Programs | |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.1080/21624054.2016.1238560 | es_ES |
dc.identifier.journal | Worm | es_ES |
dc.repisalud.centro | ISCIII::Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC) | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/642 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/120 | es_ES |
dc.rights.accessRights | open access | es_ES |