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dc.contributor.authorLozano, Encarnación 
dc.contributor.authorde Lucas, Maria Pilar 
dc.contributor.authorSáez, Alberto G 
dc.date.accessioned2021-06-15T19:14:31Z
dc.date.available2021-06-15T19:14:31Z
dc.date.issued2016
dc.identifier.citationWorm . 2016 Sep 21;5(4):e1238560.es_ES
dc.identifier.issn2162-4046es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/13139
dc.description.abstractThe miR-58 family comprises 6 microRNAs with largely shared functions, and with an overall high expression, because one of its members, miR-58, is the most abundant microRNA in Caenorhabditis elegans. We recently found that 2 TGF-β signaling pathways, Sma/Mab and Dauer, responsible for body size and dauer formation respectively, among other phenotypes, are downregulated by the miR-58 family. Here, we further explore this family by showing that it also acts through the sta-1 3'UTR. sta-1 encodes a transcription factor, homologous to mammalian STATs, that inhibits dauer formation in association with the TGF-β Dauer pathway. We also observe that mutants with a constitutively active TGF-β Dauer pathway express higher levels of sta-1 mRNA. Our results reinforce the view of the miR-58 family and STA-1 as regulators of dauer formation in coordination with the TGF-β Dauer pathway.es_ES
dc.description.sponsorshipThis work was funded by Fondo de Investigaciones Sanitarias (PI08/642 and PI11/120 to E.L.). E.L., M.P.L. and A.G.S. were supported by programs Ramón y Cajal, Formación de Profesorado Universitario and Fondo de Investigaciones Sanitarias, respectively, all of them from the Spanish Government. C. elegans strains were provided by CGC, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440).es_ES
dc.language.isoenges_ES
dc.publisherTaylor and Francises_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectDaueres_ES
dc.subjectTGF-β Daueres_ES
dc.subjectMicroRNAses_ES
dc.subjectMir-58es_ES
dc.subjectSta-1es_ES
dc.titlesta-1 is repressed by mir-58 family in Caenorhabditis elegans.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial 4.0 Internacional*
dc.identifier.pubmedID28090395es_ES
dc.format.volume5es_ES
dc.format.number4es_ES
dc.format.pagee1238560es_ES
dc.identifier.doi10.1080/21624054.2016.1238560es_ES
dc.contributor.funderFondo de Investigaciones Sanitariases_ES
dc.contributor.funderNIH Office of Research Infrastructure Programses_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1080/21624054.2016.1238560es_ES
dc.identifier.journalWormes_ES
dc.repisalud.centroISCIII::Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC)es_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/642es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/120es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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