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dc.contributor.authorCaballero-Casero, Noelia
dc.contributor.authorBelova, Lidia
dc.contributor.authorVervliet, Philippe
dc.contributor.authorAntignac, Jean-Philippe
dc.contributor.authorCastaño, Argelia 
dc.contributor.authorDebrauwer, Laurent
dc.contributor.authorEsteban-Lopez, Marta 
dc.contributor.authorHuber, Carolin
dc.contributor.authorKlanova, Jana
dc.contributor.authorKrauss, Martin
dc.contributor.authorLommen, Arjen
dc.contributor.authorMol, Hans G.J.
dc.contributor.authorOberacher, Herbert
dc.contributor.authorPardo, Olga
dc.contributor.authorPrice, Elliott J.
dc.contributor.authorReinstadler, Vera
dc.contributor.authorVitale, Chiara Maria
dc.contributor.authorvan Nuijs, Alexander L.N.
dc.contributor.authorCovaci, Adrian
dc.date.accessioned2021-06-02T14:49:58Z
dc.date.available2021-06-02T14:49:58Z
dc.date.issued2021
dc.identifier.citationTrends Analyt Chem. 2021; 136:11620es_ES
dc.identifier.issn0165-9936es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/13062
dc.description.abstractAlthough the exposure assessment of chemicals of emerging concern (CECs) has taken a decisive step forward through advances in (bio)informatics, statistics, and the development of highly sophisticated analytical instruments, the lack of standardisation and harmonisation of analytical workflows and method performance assessment for suspect and non-target screening hampers the interpretation of results, their comparability and thus, its transmission to policymakers. To date, unlike in other research fields such as forensics or food analysis, there is a lack of guidelines for non-target analysis in human risk assessment and quality assurance and quality control (QA/QC) protocols. Moreover, the majority of efforts have been focused on the development and implementation of QA/QC actions for data acquisition, data analysis and mining, largely neglecting the sample preparation necessary for determination of CECs by suspect and non-target screening methods. In this article, we propose a set of QA/QC measures that covers sampling, sample preparation and data acquisition, as an aspect of work conducted within the European Biomonitoring for Europe initiative (HBM4EU). These measures include the use of standardised terminology and the implementation of dedicated QA/QC actions in each stage of the analytical process. Moreover, a framework for the analytical performance assessment has been developed for the first time for the identification of CECs in human samples by suspect and non-target approaches. Adoption of the actions proposed here for the identification of CECs in human matrices can significantly improve the comparability of reported results and contribute to the (challenging) Exposome research field.es_ES
dc.description.sponsorshipThe authors thank the European Union’s Horizon 2020 research and innovation programme HBM4EU (Grant Agreement No. 733032) for its financial support. Dr. N. Caballero-Casero acknowledges postdoctoral fellowship from the University of Antwerp. Drs. P. Vervliet acknowledges funding through a Research Foundation Flanders project (G089016N). Drs. L. Belova acknowledges funding through a Research Foundation Flanders project (11G1821N). This work was also supported by the Exposome Centre of Excellence of the University of Antwerp (BOF grant, Antigoon database number 41222). Dr. E.J. Price acknowledges support from the Czech Operational Programme Research, Development and Education – Project Postdoc@MUNI (No. CZ.02.2.69/0.0/0.0/16_027/0008360).es_ES
dc.language.isoenges_ES
dc.publisherElsevier es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectQuality control-quality assurance measureses_ES
dc.subjectFramework for analytical performancees_ES
dc.subjectEmerging compoundses_ES
dc.subjectHuman matriceses_ES
dc.subjectSuspect and non-target screeninges_ES
dc.subjectHBM4EUes_ES
dc.titleTowards harmonised criteria in quality assurance and quality control of suspect and non-target LC-HRMS analytical workflows for screening of emerging contaminants in human biomonitoringes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.format.volume136es_ES
dc.format.page116201es_ES
dc.identifier.doi10.1016/j.trac.2021.116201es_ES
dc.contributor.funderUnión Europea. Comisión Europea. H2020 es_ES
dc.contributor.funderResearch Foundation - Flanders es_ES
dc.contributor.funderUniversity of Antwerp (Bélgica) es_ES
dc.contributor.funderCzech Operational Programme Researches_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.trac.2021.116201es_ES
dc.identifier.journalTrAC Trends in Analytical Chemistryes_ES
dc.repisalud.centroISCIII::Centro Nacional de Sanidad Ambientales_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/H2020/733032es_ES
dc.rights.accessRightsopen accesses_ES


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