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dc.contributor.authorGarcía, Vanesa
dc.contributor.authorMandomando, Inácio
dc.contributor.authorRuiz, Joaquim
dc.contributor.authorHerrera-Leon, Silvia 
dc.contributor.authorAlonso, Pedro L
dc.contributor.authorRodicio, M Rosario
dc.identifier.citationInfect Drug Resist. 2018 Jan 31;11:195-204.es_ES
dc.description.abstractInvasive nontyphoidal salmonellosis, mostly caused by serovars Typhimurium and Enteritidis of Salmonella enterica, has emerged as a major public health problem in sub-Saharan Africa. The aim of this study was the clinical and microbiological characterization of nontyphoidal salmonellosis episodes affecting febrile children in Mozambique. The clinical records of the patients were evaluated, and S. enterica isolates were characterized with regard to serovar, phage type, antimicrobial resistance (phenotype/responsible genes), plasmid content, pulsed-field gel electrophoresis, and multilocus sequence typing. Fifteen S. Typhimurium and 21 S. Enteritidis isolates were recovered from blood samples of 25 children, the majority with underlying risk factors. With regard to phage typing, most isolates were either untypeable or reacted but did not conform, revealing that a number of previously unrecognized patterns are circulating in Mozambique. Most isolates were multidrug-resistant, with nearly all of the responsible genes located on derivatives of serovar-specific virulence plasmids. ST313 and ST11 were the predominant sequence types associated with S. Typhimurium and S. Enteritidis, respectively, and the uncommon ST1479 was also detected in S. Enteritidis. A distinct XbaI fragment of ~350 kb was associated with pulsed-field gel electrophoresis patterns of multidrug-resistant isolates of S. Enteritidis. Nearly half of the children were coinfected with both serovars, a fact expected to aggravate the disease and hamper the treatment. However, particularly poor outcomes were not observed for the coinfected patients. Mixed Salmonella infections could frequently occur in febrile children in Mozambique. Additional studies are required to determine their actual impact and consequences, not only in this country, but also in other African countries.es_ES
dc.description.sponsorshipThis work was supported by projects UO-15-INVES-09 (Consejería de Educación, Cultura y Deporte, Principado de Asturias, Spain) and FIS PI11-00808 and FIS PI14CIII/00051 (Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, Spain, cofunded by European Regional Development Fund of the European Union). CISM received core funding from the Spanish Agency for International Cooperation and Development. JR was supported by a fellowship from the program I3, of the ISCIII (Grant Number: CES11/012).es_ES
dc.publisherDove Medical Presses_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subjectbloodstream infectiones_ES
dc.subjectinvasive nontyphoidal salmonellosises_ES
dc.subjectmultidrug resistancees_ES
dc.subjectvirulence-resistance plasmides_ES
dc.titleSalmonella enterica serovars Typhimurium and Enteritidis causing mixed infections in febrile children in Mozambique.es_ES
dc.rights.licenseAtribución-NoComercial 4.0 Internacional*
dc.contributor.funderGobierno del Principado de Asturiases_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderAgencia Española de Cooperación Internacional para el Desarrolloes_ES
dc.identifier.journalInfection and Drug Resistancees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/FIS PI11-00808es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/FIS PI14CIII/00051es_ES

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