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dc.contributor.authorBlanco Vázquez, Cristina
dc.contributor.authorBarral, Thiago Doria
dc.contributor.authorRomero, Beatriz
dc.contributor.authorQueipo, Manuel
dc.contributor.authorMerediz, Isabel
dc.contributor.authorQuirós, Pablo
dc.contributor.authorArmenteros, José Ángel
dc.contributor.authorJuste, Ramón
dc.contributor.authorDomínguez, Lucas
dc.contributor.authorDominguez-Rodriguez, Mercedes 
dc.contributor.authorCasais, Rosa
dc.contributor.authorBalseiro, Ana
dc.identifier.citationAnimals (Basel). 2021 Apr 30;11(5):1294.es_ES
dc.description.abstractThe present work investigated the prevalence, spatial distribution, and temporal distribution of tuberculosis (TB) in free-ranging Eurasian badgers (Meles meles) and cattle in Asturias (Atlantic Spain) during a 13-year follow-up. The study objective was to assess the role of badgers as a TB reservoir for cattle and other sympatric wild species in the region. Between 2008 and 2020, 673 badgers (98 trapped and 575 killed in road traffic accidents) in Asturias were necropsied, and their tissue samples were cultured for the Mycobacterium tuberculosis complex (MTC) isolation. Serum samples were tested in an in-house indirect P22 ELISA to detect antibodies against the MTC. In parallel, data on MTC isolation and single intradermal tuberculin test results were extracted for cattle that were tested and culled as part of the Spanish National Program for the Eradication of Bovine TB. A total of 27/639 badgers (4.23%) were positive for MTC based on bacterial isolation, while 160/673 badgers (23.77%) were found to be positive with the P22 ELISA. The rate of seropositivity was higher among adult badgers than subadults. Badger TB status was spatially and temporally associated with cattle TB status. Our results cannot determine the direction of possible interspecies transmission, but they are consistent with the idea that the two hosts may exert infection pressure on each other. This study highlights the importance of the wildlife monitoring of infection and disease during epidemiological interventions in order to optimize outcomes.es_ES
dc.description.sponsorshipThis work was funded by the Ministerio de Ciencia, Innovación y Universidades (MCIU), the Agencia Estatal de Investigación (AEI) reference project RTI2018-096010-B-C21 (FEDER cofunded), PCTI 2018–2020 (GRUPIN: IDI2018-000237), and FEDER and Ministerio de Agricultura, Pesca y Alimentación. C.B.V. was supported by a grant from the Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Spain. Publication costs were covered with funds from RTI2018-096010-B-C21 (FEDER co-funded). T.D.B. was supported by a fellowship from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES; process number 88887.511077/2020-00).es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subjectAtlantic Spaines_ES
dc.subjectMeles meleses_ES
dc.subjectMycobacterium tuberculosis complexes_ES
dc.subjectP22 ELISAes_ES
dc.titleSpatial and Temporal Distribution of Mycobacterium tuberculosis Complex Infection in Eurasian Badger (Meles meles) and Cattle in Asturias, Spain.es_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderAgencia Estatal de Investigación (España)es_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderMinisterio de Agricultura, Pesca y Alimentaciónes_ES
dc.contributor.funderInstituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), España.es_ES
dc.contributor.funderCoordenação de Aperfeiçoamento de Pessoal de Nível Superiores_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/GRUPIN: IDI2018-000237es_ES

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