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dc.contributor.authorde Lucas, Beatriz
dc.contributor.authorPérez, Laura M
dc.contributor.authorBernal, Aurora 
dc.contributor.authorGálvez, Beatriz G
dc.date.accessioned2021-05-05T06:41:47Z
dc.date.available2021-05-05T06:41:47Z
dc.date.issued2020-09
dc.identifier.citationGenes (Basel). 2020; 11(9):1086es_ES
dc.identifier.issn2073-4425es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/12866
dc.description.abstractUltrasound has emerged as a novel tool for clinical applications, particularly in the context of regenerative medicine. Due to its unique physico-mechanical properties, low-intensity ultrasound (LIUS) has been approved for accelerated fracture healing and for the treatment of established non-union, but its utility has extended beyond tissue engineering to other fields, including cell regeneration. Cells and tissues respond to acoustic ultrasound by switching on genetic repair circuits, triggering a cascade of molecular signals that promote cell proliferation, adhesion, migration, differentiation, and extracellular matrix production. LIUS also induces angiogenesis and tissue regeneration and has anti-inflammatory and anti-degenerative effects. Accordingly, the potential application of ultrasound for tissue repair/regeneration has been tested in several studies as a stand-alone treatment and, more recently, as an adjunct to cell-based therapies. For example, ultrasound has been proposed to improve stem cell homing to target tissues due to its ability to create a transitional and local gradient of cytokines and chemokines. In this review, we provide an overview of the many applications of ultrasound in clinical medicine, with a focus on its value as an adjunct to cell-based interventions. Finally, we discuss the various preclinical and clinical studies that have investigated the potential of ultrasound for regenerative medicine.es_ES
dc.description.sponsorshipThis research was funded by Ministerio de Ciencia, Innovación y Universidades, grant number SAF2015-67911-R.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshRegenerative Medicine es_ES
dc.subject.meshUltrasonic Waves es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshHumans es_ES
dc.subject.meshStem Cells es_ES
dc.titleUltrasound Therapy: Experiences and Perspectives for Regenerative Medicine.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID32957737es_ES
dc.format.volume11es_ES
dc.format.number9es_ES
dc.identifier.doi10.3390/genes11091086es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3390/genes11091086es_ES
dc.identifier.journalGeneses_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Nanomedicina e Imagen Moleculares_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-67911-Res_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución 4.0 Internacional
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