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dc.contributor.author | de Lucas, Beatriz | |
dc.contributor.author | Pérez, Laura M | |
dc.contributor.author | Bernal, Aurora | |
dc.contributor.author | Gálvez, Beatriz G | |
dc.date.accessioned | 2021-05-05T06:41:47Z | |
dc.date.available | 2021-05-05T06:41:47Z | |
dc.date.issued | 2020-09 | |
dc.identifier.citation | Genes (Basel). 2020; 11(9):1086 | es_ES |
dc.identifier.issn | 2073-4425 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/12866 | |
dc.description.abstract | Ultrasound has emerged as a novel tool for clinical applications, particularly in the context of regenerative medicine. Due to its unique physico-mechanical properties, low-intensity ultrasound (LIUS) has been approved for accelerated fracture healing and for the treatment of established non-union, but its utility has extended beyond tissue engineering to other fields, including cell regeneration. Cells and tissues respond to acoustic ultrasound by switching on genetic repair circuits, triggering a cascade of molecular signals that promote cell proliferation, adhesion, migration, differentiation, and extracellular matrix production. LIUS also induces angiogenesis and tissue regeneration and has anti-inflammatory and anti-degenerative effects. Accordingly, the potential application of ultrasound for tissue repair/regeneration has been tested in several studies as a stand-alone treatment and, more recently, as an adjunct to cell-based therapies. For example, ultrasound has been proposed to improve stem cell homing to target tissues due to its ability to create a transitional and local gradient of cytokines and chemokines. In this review, we provide an overview of the many applications of ultrasound in clinical medicine, with a focus on its value as an adjunct to cell-based interventions. Finally, we discuss the various preclinical and clinical studies that have investigated the potential of ultrasound for regenerative medicine. | es_ES |
dc.description.sponsorship | This research was funded by Ministerio de Ciencia, Innovación y Universidades, grant number SAF2015-67911-R. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Regenerative Medicine | es_ES |
dc.subject.mesh | Ultrasonic Waves | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Stem Cells | es_ES |
dc.title | Ultrasound Therapy: Experiences and Perspectives for Regenerative Medicine. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 32957737 | es_ES |
dc.format.volume | 11 | es_ES |
dc.format.number | 9 | es_ES |
dc.identifier.doi | 10.3390/genes11091086 | es_ES |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/genes11091086 | es_ES |
dc.identifier.journal | Genes | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Nanomedicina e Imagen Molecular | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2015-67911-R | es_ES |
dc.rights.accessRights | open access | es_ES |