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dc.contributor.authorFabris, Enrico
dc.contributor.authorHermanides, Renicus
dc.contributor.authorRoolvink, Vincent
dc.contributor.authorIbanez, Borja 
dc.contributor.authorOttervanger, Jan Paul
dc.contributor.authorPizarro, Gonzalo 
dc.contributor.authorvan Royen, Niels
dc.contributor.authorMateos-Rodriguez, Alonso
dc.contributor.authorDambrink, Jan Henk
dc.contributor.authorAlbarran, Agustin
dc.contributor.authorFernández-Avilés, Francisco
dc.contributor.authorBotas, Javier
dc.contributor.authorRemkes, Wouter
dc.contributor.authorHernandez-Jaras, Victoria
dc.contributor.authorKedhi, Elvin
dc.contributor.authorZamorano, Jose
dc.contributor.authorAlfonso, Fernando
dc.contributor.authorGarcía-Lledó, Alberto
dc.contributor.authorvan Leeuwen, Maarten
dc.contributor.authorNijveldt, Robin
dc.contributor.authorPostma, Sonja
dc.contributor.authorKolkman, Evelien
dc.contributor.authorGosselink, Marcel
dc.contributor.authorde Smet, Bart
dc.contributor.authorRasoul, Saman
dc.contributor.authorLipsic, Erik
dc.contributor.authorPiek, Jan J
dc.contributor.authorFuster, Valentin 
dc.contributor.authorvan 't Hof, Arnoud Wj
dc.date.accessioned2021-05-04T07:09:10Z
dc.date.available2021-05-04T07:09:10Z
dc.date.issued2020-12-16
dc.identifier.citationOpen Heart. 2020; 7(2):e001316es_ES
dc.identifier.issn2053-3624es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/12849
dc.description.abstractThe effect of early intravenous (IV) beta-blockers (BBs) administration in patients undergoing primary percutaneous coronary intervention (pPCI) on ST-segment deviation is unknown. We undertook a prespecified secondary analysis of the Early Beta-blocker Administration before primary PCI in patients with ST-elevation Myocardial Infarction (EARLY-BAMI) trial to investigate the effect of early IV BB on ST-segment deviation. The EARLY-BAMI trial randomised patients with ST-elevation myocardial infarction (STEMI) to IV metoprolol (2×5 mg bolus) or matched placebo before pPCI. The prespecified outcome, evaluated by an independent core laboratory blinded to study treatment, was the residual ST-segment deviation 1 hour after pPCI (ie, the percentage of patients with >3 mm cumulative ST deviation at 1 hour after pPCI). An ECG for the evaluation of residual ST-segment deviation 1 hour after pPCI was available in 442 out of 683 randomised patients. The BB group had a lower heart rate after pPCI compared with placebo (71.2±13.2 vs 74.3±13.6, p=0.016); however, no differences were noted in the percentages of patients with >3 mm cumulative ST deviation at 1 hour after pPCI (58.6% vs 54.1%, p=0.38, in BB vs placebo, respectively) neither a significant difference was found for the percentages of patients in each of the four prespecified groups (normalised ST-segment; 1-3 mm; 4-6 mm;>6 mm residual ST-deviation). In patients with STEMI, who were being transported for primary PCI, early IV BB administration did not significantly affect ST-segment deviation after pPCI compared with placebo. The neutral result of early IV BB administration on an early marker of pharmacological effect is consistent with the absence of subsequent improvement of clinical outcomes.es_ES
dc.description.sponsorshipTrial funding came from a research grant of the Dutch Heart Foundation (Utrecht, the Netherlands, no. 2010B125) and an unrestricted grant by Medtronic Inc. (Heerlen, the Netherlands), which was used for additional analyseses_ES
dc.language.isoenges_ES
dc.publisherBMJ Publishing Groupes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleBeta-blocker effect on ST-segment: a prespecified analysis of the EARLY-BAMI randomised trial.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID33318150es_ES
dc.format.volume7es_ES
dc.format.number2es_ES
dc.identifier.doi10.1136/openhrt-2020-001316es_ES
dc.contributor.funderDutch Heart Foundationes_ES
dc.contributor.funderMedtronic Inces_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://openheart.bmj.com/content/7/2/e001316.longes_ES
dc.identifier.journalOpen heartes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Arritmias Cardíacases_ES
dc.repisalud.institucionCNICes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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