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dc.contributor.authorPaget, W John
dc.contributor.authorBalderston, Catherine
dc.contributor.authorCasas, Inmaculada 
dc.contributor.authorDonker, Gé
dc.contributor.authorEdelman, Laurel
dc.contributor.authorFleming, Douglas
dc.contributor.authorLarrauri, Amparo 
dc.contributor.authorMeijer, Adam
dc.contributor.authorPuzelli, Simona
dc.contributor.authorRizzo, Caterina
dc.contributor.authorSimonsen, Lone
dc.date.accessioned2021-04-29T11:25:05Z
dc.date.available2021-04-29T11:25:05Z
dc.date.issued2010-08
dc.identifier.citationEur J Pediatr. 2010;169(8):997-1008.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/12829
dc.description.abstractThe European Paediatric Influenza Analysis (EPIA) project is a multi-country project that was created to collect, analyse and present data regarding the paediatric influenza burden in European countries, with the purpose of providing the necessary information to make evidence-based decisions regarding influenza immunisation recommendations for children. The initial approach taken is based on existing weekly virological and age-specific influenza-like illness (ILI) data from surveillance networks across Europe. We use a multiple regression model guided by longitudinal weekly patterns of influenza virus to attribute the weekly ILI consultation incidence pattern to each influenza (sub)type, while controlling for the effect of respiratory syncytial virus (RSV) epidemics. Modelling the ILI consultation incidence during 2002/2003-2008 revealed that influenza infections that presented for medical attention as ILI affected between 0.3% and 9.8% of children aged 0-4 and 5-14 years in England, Italy, the Netherlands and Spain in an average season. With the exception of Spain, these rates were always higher in children aged 0-4 years. Across the six seasons analysed (five seasons were analysed from the Italian data), the model attributed 47-83% of the ILI burden in primary care to influenza virus infection in the various countries, with the A(H3N2) virus playing the most important role, followed by influenza viruses B and A(H1N1). National season averages from the four countries studied indicated that between 0.4% and 18% of children consulted a physician for ILI, with the percentage depending on the country and health care system. Influenza virus infections explained the majority of paediatric ILI consultations in all countries. The next step will be to apply the EPIA modelling approach to severe outcomes indicators (i.e. hospitalisations and mortality data) to generate a complete range of mild and severe influenza burden estimates needed for decision making concerning paediatric influenza vaccination.es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectInfluenzaes_ES
dc.subjectChildrenes_ES
dc.subjectPaediatrices_ES
dc.subjectBurdenes_ES
dc.subjectofdiseasees_ES
dc.subjectModellinges_ES
dc.subjectEuropees_ES
dc.subject.meshMass Vaccination es_ES
dc.subject.meshAdolescent es_ES
dc.subject.meshAge Factors es_ES
dc.subject.meshChild es_ES
dc.subject.meshChild, Preschool es_ES
dc.subject.meshEurope es_ES
dc.subject.meshEvidence-Based Practice es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshIncidence es_ES
dc.subject.meshInfant es_ES
dc.subject.meshInfluenza A Virus, H1N1 Subtype es_ES
dc.subject.meshInfluenza A Virus, H3N2 Subtype es_ES
dc.subject.meshInfluenza A virus es_ES
dc.subject.meshInfluenza Vaccines es_ES
dc.subject.meshInfluenza, Humanes_ES
dc.subject.meshInterleukin-1 es_ES
dc.subject.meshLongitudinal Studies es_ES
dc.subject.meshMale es_ES
dc.subject.meshPopulation Surveillance es_ES
dc.subject.meshRegression Analysis es_ES
dc.subject.meshRespiratory Syncytial Viruses es_ES
dc.titleAssessing the burden of paediatric influenza in Europe: the European Paediatric Influenza Analysis (EPIA) project.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial 4.0 Internacional*
dc.identifier.pubmedID20229049es_ES
dc.format.volume169es_ES
dc.format.number8es_ES
dc.format.page997-1008es_ES
dc.identifier.doi10.1007/s00431-010-1164-0es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1432-1076es_ES
dc.relation.publisherversionhttps://doi.org/10.1007/s00431-010-1164-0es_ES
dc.identifier.journalEuropean Journal of Pediatricses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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