Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/12783
Spread of Streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant Clone, Spain.
Emerg Infect Dis. 2014 Nov;20(11):1848-56.
Since 2004, a total of 131 isolates of Streptococcus pneumoniae multidrug-resistant invasive serotype 8 have been detected in Spain. These isolates showed resistance to erythromycin, clindamycin, tetracycline, and ciprofloxacin. All isolates were obtained from adult patients and shared a common genotype (sequence type [ST]63; penicillin-binding protein 1a [pbp1a], pbp2b, and pbp2x gene profiles; ermB and tetM genes; and a ParC-S79F change). Sixty-eight isolates that required a ciprofloxacin MIC ≥16 μg/mL had additional gyrA gene changes. Serotype 8-ST63 pbp2x sequences were identical with those of antimicrobial drug-susceptible serotype 8-ST53 isolates. Serotype 8-ST63 pbp2b sequences were identical with those of the multidrug-resistant Sweden 15A-ST63 clone. Recombination between the capsular locus and flanking regions of an ST53 isolate (donor) and an ST63 pneumococcus (recipient) generated the novel 15A-ST63 clone. One recombination point was upstream of pbp2x and another was within pbp1a. A serotype 8-ST63 clone was identified as a cause of invasive disease in Spain.
Drug Resistance, Multiple, Bacterial | Recombination, Genetic | Adolescent | Adult | Amino Acid Sequence | Anti-Bacterial Agents | Bacterial Proteins | Base Sequence | Child | Codon | Gene Order | Genome, Bacterial | Genotype | Humans | Microbial Sensitivity Tests | Molecular Sequence Data | Molecular Typing | Phenotype | Pneumococcal Infections | Polymorphism, Genetic | Serogroup | Spain | Streptococcus pneumoniae | Young Adult
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