Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/12709
Título
Brain metastasis models: What should we aim to achieve better treatments?
Autor(es)
Fecha de publicación
2021-02
Cita
Adv Drug Deliv Rev.2021 Feb;169:79-99.
Idioma
Inglés
Tipo de documento
preprint
Resumen
Brain metastasis is emerging as a unique entity in oncology based on its particular biology and, consequently, the pharmacological approaches that should be considered. We discuss the current state of modelling this specific progression of cancer and how these experimental models have been used to test multiple pharmacologic strategies over the years. In spite of pre-clinical evidences demonstrating brain metastasis vulnerabilities, many clinical trials have excluded patients with brain metastasis. Fortunately, this trend is getting to an end given the increasing importance of secondary brain tumors in the clinic and a better knowledge of the underlying biology. We discuss emerging trends and unsolved issues that will shape how we will study experimental brain metastasis in the years to come.
Palabras clave
EXPERIMENTAL MODELS | PRECLINICAL THERAPY | BRAIN METASTASIS | ORGANOTROPISM | BBB | BTB | SMALL-MOLECULE DRUGS | NANOMEDICINES | IMMUNOTHERAPY
Versión en línea
DOI
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- Nombre:
- Brainmetastasismodelswhat_2021.pdf
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- 1.342Mb
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