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dc.contributor.authorParker, Lucy A
dc.contributor.authorAcosta, Lucrecia
dc.contributor.authorGutierrez, Mariana Noel
dc.contributor.authorCruz, Israel 
dc.contributor.authorNieto, Javier 
dc.contributor.authorDeschutter, Enrique Jorge
dc.contributor.authorBornay-Llinares, Fernando Jorge
dc.identifier.citationFront Vet Sci . 2021 Mar 8;8:642287es_ES
dc.description.abstractBackground: Visceral leishmaniasis (VL) is one of the most important parasitic diseases in the world. The domestic dog is the main reservoir of zoonotic VL and a high prevalence of canine leishmaniasis (CanL) is associated with transmission of infection to humans. Here we describe the methodology used to obtain a rapid and representative sample of domestic dogs in the city of Posadas, Misiones, and compare the prevalence of Leishmania infection with a sample of shelter dogs. Methodology: We used the city land registry to make a random selection of homes and systematically recruited 349 domestic dogs from the selected properties. We also included all dogs from the main canine shelter within the city. Dogs were examined by two experienced veterinarians who recorded the presence of clinical signs common in CanL using a standardized protocol. We extracted a blood sample from each dog and performed four different serological tests to reveal the presence of anti-Leishmania antibodies. Results: After clinical examination, 145 domestic dogs (41.5%) and 63 (90%) shelter dogs had clinical signs compatible with CanL (p < 0.001). The seroprevalence among domestic dogs was 20.1% (95% CI 16.1-24.6) which was significantly lower than among the abandoned dogs (38.6%, 95% CI 27.7-50.6, p < 0.001). The spatial distribution of infected dogs was fairly homogenous throughout the city. Among domestic dogs, we observed a positive association between where the dog slept and presence of anti-Leishmania antibodies (p = 0.034). Of the seropositive domestic dogs 38 (54.4%) were asymptomatic. Conclusions: Our findings demonstrate how seroprevalence results can be highly influenced by sampling methodology. We demonstrate how the land registry can be used to estimate the prevalence of CanL in representative sample of domestic dogs in an urban setting, allowing decision makers to deepen their understanding the epidemiology of CanL in a timely and efficient manner for the development of plans to address both human and canine disease.es_ES
dc.description.sponsorshipThis work was supported by: Dirección General de Cooperación al Desarrollo, Generalitat Valenciana, Spain (Ref. 3014/2008) and European Commission 6th Framework Programme INCO-CT-2005-015407 [Control strategies for visceral leishmaniasis (VL) and mucocutaneous leishmaniasis (MCL) in South America: Applications of molecular epidemiology/LeishEpiNetSA].es_ES
dc.publisherFrontiers Mediaes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subjectvisceral leishmaniasises_ES
dc.subjectcanine leishmaniasises_ES
dc.subjectcanine populationes_ES
dc.titleA Novel Sampling Model to Study the Epidemiology of Canine Leishmaniasis in an Urban Environment.es_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funder6º Programa Marco - Comisión Europeaes_ES
dc.contributor.funderGeneralitat Valencianaes_ES
dc.identifier.journalFrontiers in veterinary sciencees_ES
dc.repisalud.centroISCIII::Escuela Nacional de Sanidades_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES

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