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dc.contributor.authorLópez-Janeiro, Álvaro
dc.contributor.authorRuz-Caracuel, Ignacio
dc.contributor.authorRamón-Patino, Jorge L
dc.contributor.authorDe Los Ríos, Vivian
dc.contributor.authorVillalba Esparza, María
dc.contributor.authorBerjón, Alberto
dc.contributor.authorYébenes, Laura
dc.contributor.authorHernández, Alicia
dc.contributor.authorMasetto, Ivan
dc.contributor.authorKadioglu, Ece
dc.contributor.authorGoubert, Virginie
dc.contributor.authorHeredia-Soto, Victoria
dc.contributor.authorBarderas Manchado, Rodrigo 
dc.contributor.authorCasal, José Ignacio
dc.contributor.authorde Andrea, Carlos E
dc.contributor.authorRedondo, Andrés
dc.contributor.authorMendiola, Marta
dc.contributor.authorPeláez-García, Alberto
dc.contributor.authorHardisson, David
dc.date.accessioned2021-04-13T18:22:06Z
dc.date.available2021-04-13T18:22:06Z
dc.date.issued2021-02-14
dc.identifier.citationCancers (Basel) . 2021 Feb 14;13(4):794.es_ES
dc.identifier.issn2072-6694es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/12638
dc.description.abstractLow-grade, early-stage endometrial carcinoma (EC) is the most frequent malignant tumor of the uterine corpus. However, the molecular alterations that underlie these tumors are far from being fully understood. The purpose of this study is to describe dysregulated molecular pathways from EC patients. Sixteen samples of tumor tissue and paired healthy controls were collected and both were subjected to mass spectrometry (MS)/MS proteomic analysis. Gene ontology and pathway analysis was performed to discover dysregulated pathways and/or proteins using different databases and bioinformatic tools. Dysregulated pathways were cross-validated in an independent external cohort. Cell signaling, immune response, and cell death-associated pathways were robustly identified. The SLIT/ROBO signaling pathway demonstrated dysregulation at the proteomic and transcriptomic level. Necroptosis and ferroptosis were cell death-associated processes aberrantly regulated, in addition to apoptosis. Immune response-associated pathways showed a dominance of innate immune responses. Tumor immune infiltrates measured by immunofluorescence demonstrated diverse lymphoid and myeloid populations. Our results suggest a role of SLIT/ROBO, necroptosis, and ferroptosis, as well as a prominent role of innate immune response in low-grade, early-stage EC. These results could guide future research in this group of tumors.es_ES
dc.description.sponsorshipThis research was funded by the Instituto de Salud Carlos III (ISCIII) (PI17/01723), co-financed by the European Development Regional Fund “A way to achieve Europe” (FEDER).es_ES
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectSLIT/ROBOes_ES
dc.subjectEndometrial canceres_ES
dc.subjectFerroptosises_ES
dc.subjectImmune microenvironmentes_ES
dc.subjectLow gradees_ES
dc.subjectNecroptosises_ES
dc.subjectPathwayses_ES
dc.subjectProteomicses_ES
dc.titleProteomic Analysis of Low-Grade, Early-Stage Endometrial Carcinoma Reveals New Dysregulated Pathways Associated with Cell Death and Cell Signaling.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID33672863es_ES
dc.format.volume13es_ES
dc.format.number4es_ES
dc.identifier.doi10.3390/cancers13040794es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3390/cancers13040794es_ES
dc.identifier.journalCancerses_ES
dc.repisalud.centroISCIII::Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC)es_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI17/01723es_ES
dc.rights.accessRightsopen accesses_ES


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