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dc.contributor.authorVinuesa, Víctor
dc.contributor.authorMcConnell, Michael J 
dc.date.accessioned2021-04-11T13:12:29Z
dc.date.available2021-04-11T13:12:29Z
dc.date.issued2021-03-12
dc.identifier.citationInt J Mol Sci . 2021 Mar 12;22(6):2876. des_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/12598
dc.description.abstractIron is essential for multiple bacterial processes and is thus required for host colonization and infection. The antimicrobial activity of multiple iron chelators and gallium-based therapies against different bacterial species has been characterized in preclinical studies. In this review, we provide a synthesis of studies characterizing the antimicrobial activity of the major classes of iron chelators (hydroxamates, aminocarboxylates and hydroxypyridinones) and gallium compounds. Special emphasis is placed on recent in-vitro and in-vivo studies with the novel iron chelator DIBI. Limitations associated with iron chelation and gallium-based therapies are presented, with emphasis on limitations of preclinical models, lack of understanding regarding mechanisms of action, and potential host toxicity. Collectively, these studies demonstrate potential for iron chelators and gallium to be used as antimicrobial agents, particularly in combination with existing antibiotics. Additional studies are needed in order to characterize the activity of these compounds under physiologic conditions and address potential limitations associated with their clinical use as antimicrobial agents.es_ES
dc.description.sponsorshipThis research was supported by grants MPY 380/18 from the Instituto de Salud Carlos III (ISCIII) awarded to M.J.M. V.V. is supported by the Río Hortega Program from the Instituto de Salud Carlos III.es_ES
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDIBIes_ES
dc.subjectGalliumes_ES
dc.subjectIron acquisitiones_ES
dc.subjectIron chelatorses_ES
dc.subjectMultidrug resistant bacteriaes_ES
dc.subjectSynergyes_ES
dc.titleRecent Advances in Iron Chelation and Gallium-Based Therapies for Antibiotic Resistant Bacterial Infections.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID33809032es_ES
dc.format.volume22es_ES
dc.format.number6es_ES
dc.identifier.doi10.3390/ijms22062876es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1422-0067es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/ijms22062876es_ES
dc.identifier.journalInternational journal of molecular scienceses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MPY 380/18es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional