Show simple item record

dc.contributor.authorStrauss, Ricardo A
dc.contributor.authorHerrera-Leon, Laura 
dc.contributor.authorGuillén, Ana C
dc.contributor.authorCastro, Julio S
dc.contributor.authorLorenz, Eva
dc.contributor.authorCarvajal, Ana
dc.contributor.authorHernandez, Elizabeth
dc.contributor.authorNavas, Trina
dc.contributor.authorVielma, Silvana
dc.contributor.authorLopez, Neiris
dc.contributor.authorLopez, Maria G
dc.contributor.authorAurenty, Lisbeth
dc.contributor.authorNavas, Valeria
dc.contributor.authorRosas, Maria A
dc.contributor.authorDrummond, Tatiana
dc.contributor.authorMartínez, José G
dc.contributor.authorHernández, Erick
dc.contributor.authorBertuglia, Francis
dc.contributor.authorAndrade, Omaira
dc.contributor.authorTorres, Jaime
dc.contributor.authorMay, Jürgen
dc.contributor.authorHerrera-Leon, Silvia 
dc.contributor.authorEibach, Daniel
dc.identifier.citationSci Rep . 2021 Mar 18;11(1):6378.es_ES
dc.description.abstractIn 2016, Venezuela faced a large diphtheria outbreak that extended until 2019. Nasopharyngeal or oropharyngeal samples were prospectively collected from 51 suspected cases and retrospective data from 348 clinical records was retrieved from 14 hospitals between November 2017 and November 2018. Confirmed pathogenic Corynebactrium isolates were biotyped. Multilocus Sequence Typing (MLST) was performed followed by next-generation-based core genome-MLST and minimum spanning trees were generated. Subjects between 10 and 19 years of age were mostly affected (n = 95; 27.3%). Case fatality rates (CFR) were higher in males (19.4%), as compared to females (15.8%). The highest CFR (31.1%) was observed among those under 5, followed by the 40 to 49 age-group (25.0%). Nine samples corresponded to C. diphtheriae and 1 to C. ulcerans. Two Sequencing Types (ST), ST174 and ST697 (the latter not previously described) were identified among the eight C. diphtheriae isolates from Carabobo state. Cg-MLST revealed only one cluster also from Carabobo. The Whole Genome Sequencing analysis revealed that the outbreak seemed to be caused by different strains with C. diphtheriae and C. ulcerans coexisting. The reemergence and length of this outbreak suggest vaccination coverage problems and an inadequate control strategy.es_ES
dc.description.sponsorshipOpen Access funding enabled and organized by Projekt DEAL. This work was supported by the Bernhard Nocht Institute for Tropical Medicine, Department of Infectious Disease Epidemiology budget not related with any particular grant.es_ES
dc.publisherNature Publishing Group es_ES
dc.titleMolecular and epidemiologic characterization of the diphtheria outbreak in Venezuela.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderBernhard Nocht Institute for Tropical Medicine (Alemania) 
dc.identifier.journalScientific reportses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.rights.accessRightsopen accesses_ES

Files in this item

Acceso Abierto

This item appears in the following Collection(s)

Show simple item record

Atribución 4.0 Internacional
This item is licensed under a: Atribución 4.0 Internacional