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dc.contributor.authorSánchez-Alonso, Santiago
dc.contributor.authorSetti-Jerez, Giulia
dc.contributor.authorArroyo, Montserrat
dc.contributor.authorHernández, Tathiana
dc.contributor.authorMartos, Mª Inmaculada
dc.contributor.authorSánchez-Torres, Jose Miguel
dc.contributor.authorColomer, Ramon
dc.contributor.authorRamiro, Almudena R 
dc.contributor.authorAlfranca, Arantzazu 
dc.date.accessioned2021-04-08T12:17:40Z
dc.date.available2021-04-08T12:17:40Z
dc.date.issued2020-09-10
dc.identifier.citationJ Immunother Cancer. 2020; 8(2):e001187es_ES
dc.identifier.issn2051-1426es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/12563
dc.description.abstractLung cancer is one of the most frequent malignancies in humans and is a major cause of death. A number of therapies aimed at reinforcing antitumor immune response, including antiprogrammed cell death protein 1 (anti-PD-1) antibodies, are successfully used to treat several neoplasias as non-small cell lung cancer (NSCLC). However, host immune mechanisms that participate in response to anti-PD-1 therapy are not completely understood. We used a syngeneic immunocompetent mouse model of NSCLC to analyze host immune response to anti-PD-1 treatment in secondary lymphoid organs, peripheral blood and tumors, by flow cytometry, immunohistochemistry and quantitative real-time PCR (qRT-PCR). In addition, we also studied specific characteristics of selected immune subpopulations in ex vivo functional assays. We show that anti-PD-1 therapy induces a population of circulating T follicular helper cells (cTfh) with enhanced B activation capacity, which participates in tumor response to treatment. Anti-PD-1 increases the number of tertiary lymphoid structures (TLS), which correlates with impaired tumor growth. Of note, TLS support cTfh-associated local antibody production, which participates in host immune response against tumor. These findings unveil a novel mechanism of action for anti-PD-1 therapy and provide new targets for optimization of current therapies against lung cancer.es_ES
dc.description.sponsorshipThis work was supported by grants to AA: FIS PI15/01491 and CIBER CARDIOVASCULAR from the Instituto de Salud Carlos III (Fondo de Investigación Sanitaria del Instituto de Salud Carlos III with co-fundingfrom the Fondo Europeo de Desarrollo Regional; FEDER).es_ES
dc.language.isoenges_ES
dc.publisherBMJ Publishing Groupes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.titleA new role for circulating T follicular helper cells in humoral response to anti-PD-1 therapy.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial 4.0 Internacional*
dc.identifier.pubmedID32900863es_ES
dc.format.volume8es_ES
dc.format.number2es_ES
dc.identifier.doi10.1136/jitc-2020-001187es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderCentro de Investigación Biomedica en Red - CIBERes_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1136/jitc-2020-001187es_ES
dc.identifier.journalJournal for immunotherapy of canceres_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Biología de linfocitos Bes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15/01491es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial 4.0 Internacional
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