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dc.contributor.authorMartínez-García, Magdalena
dc.contributor.authorPaternina-Die, María
dc.contributor.authorBarba-Müller, Erika
dc.contributor.authorMartín de Blas, Daniel
dc.contributor.authorBeumala, Laura
dc.contributor.authorCortizo, Romina
dc.contributor.authorPozzobon, Cristina
dc.contributor.authorMarcos-Vidal, Luis
dc.contributor.authorFernández-Pena, Alberto
dc.contributor.authorPicado, Marisol
dc.contributor.authorBelmonte-Padilla, Elena
dc.contributor.authorMassó-Rodriguez, Anna
dc.contributor.authorBallesteros, Agustín
dc.contributor.authorDesco, Manuel 
dc.contributor.authorVilarroya, Óscar
dc.contributor.authorHoekzema, Elseline
dc.contributor.authorCarmona, Susanna
dc.date.accessioned2021-03-30T11:49:39Z
dc.date.available2021-03-30T11:49:39Z
dc.date.issued2021-02-03
dc.identifier.citationBrain Sci. 2021; 11(2):168es_ES
dc.identifier.issn2076-3425
dc.identifier.urihttp://hdl.handle.net/20.500.12105/12474
dc.description.abstractNeuroimaging researchers commonly assume that the brain of a mother is comparable to that of a nulliparous woman. However, pregnancy leads to pronounced gray matter volume reductions in the mother’s brain, which have been associated with maternal attachment towards the baby. Beyond two years postpartum, no study has explored whether these brain changes are maintained or instead return to pre-pregnancy levels. The present study tested whether gray matter volume reductions detected in primiparous women are still present six years after parturition. Using data from a unique, prospective neuroimaging study, we compared the gray matter volume of 25 primiparous and 22 nulliparous women across three sessions: before conception (n = 25/22), during the first months of postpartum (n = 25/21), and at six years after parturition (n = 7/5). We found that most of the pregnancy-induced gray matter volume reductions persist six years after parturition (classifying women as having been pregnant or not with 91.67% of total accuracy). We also found that brain changes at six years postpartum are associated with measures of mother-to-infant attachment. These findings open the possibility that pregnancy-induced brain changes are permanent and encourage neuroimaging studies to routinely include pregnancy-related information as a relevant demographic variable. View Full-Textes_ES
dc.description.sponsorshipThis work was supported by Ministerio de Ciencia, Innovación y Universidades project RTI2018-093952-B-100 and by Instituto de Salud Carlos III projects CP16/00096 and PI17/00064, and co-funded by European Regional Development Fund (ERDF), “A way of making Europe.” The project exAScale ProgramIng models for extreme Data procEssing (ASPIDE) has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 801091. M.M.-G. and S.C. were funded by Ministerio de Ciencia, Innovación y Universidades, Instituto de Salud Carlos III, Predoctorales de Formación en Investigación en Salud (PFIS), contract FI18/00255 and Miguel Servet Type I research contract CP16/00096, respectively) and co-funded by European Social Fund “Investing in your future.” M.P.-D. was supported by Consejería de Educación e Investigación, Comunidad de Madrid, co-funded by European Social Fund “Investing in your future” (PEJD-2018-PRE/BMD-9401). The project leading to these results has received funding from “la Caixa” Foundation under the project code LCF/PR/HR19/52160001. The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Ministerio de Ciencia, Innovación y Universidades, and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectpregnancyes_ES
dc.subjectmaternal braines_ES
dc.subjectmagnetic resonance imaginges_ES
dc.subjectneuroplasticityes_ES
dc.subjectpostpartumes_ES
dc.titleDo Pregnancy-Induced Brain Changes Reverse? The Brain of a Mother Six Years after Parturitiones_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID33525512es_ES
dc.format.volume11es_ES
dc.format.number2es_ES
dc.format.page168es_ES
dc.identifier.doi10.3390/brainsci11020168es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderHorizon 2020es_ES
dc.contributor.funderComunidad de Madrides_ES
dc.contributor.funderFundación La Caixaes_ES
dc.contributor.funderFundación ProCNICes_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3390/brainsci11020168es_ES
dc.identifier.journalBrain Scienceses_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Imagen Avanzadaes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RTI2018-093952-B-100es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CP16/00096es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI17/00064es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/FI18/00255es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CP16/00096es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/PEJD-2018-PRE/BMD-9401es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/LCF/PR/HR19/52160001es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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