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dc.contributor.authorLópez-Delgado, Alejandra C
dc.contributor.authorDelgado, Irene 
dc.contributor.authorCadenas, Vanessa
dc.contributor.authorSanchez-Cabo, Fatima 
dc.contributor.authorTorres, Miguel 
dc.date.accessioned2021-03-30T11:46:30Z
dc.date.available2021-03-30T11:46:30Z
dc.date.issued2021-01-04
dc.identifier.citationDevelopment. 2021; 148(1):dev193813es_ES
dc.identifier.issn0950-1991
dc.identifier.urihttp://hdl.handle.net/20.500.12105/12473
dc.description.abstractVertebrate axial skeletal patterning is controlled by co-linear expression of Hox genes and axial level-dependent activity of HOX protein combinations. MEIS transcription factors act as co-factors of HOX proteins and profusely bind to Hox complex DNA; however, their roles in mammalian axial patterning remain unknown. Retinoic acid (RA) is known to regulate axial skeletal element identity through the transcriptional activity of its receptors; however, whether this role is related to MEIS/HOX activity remains unknown. Here, we study the role of Meis in axial skeleton formation and its relationship to the RA pathway in mice. Meis elimination in the paraxial mesoderm produces anterior homeotic transformations and rib mis-patterning associated to alterations of the hypaxial myotome. Although Raldh2 and Meis positively regulate each other, Raldh2 elimination largely recapitulates the defects associated with Meis deficiency, and Meis overexpression rescues the axial skeletal defects in Raldh2 mutants. We propose a Meis-RA-positive feedback loop, the output of which is Meis levels, that is essential to establish anterior-posterior identities and patterning of the vertebrate axial skeleton.es_ES
dc.description.sponsorshipThis research was supported by the Ministerio de Ciencia, Innovación y Universidades (PGC2018-096486-B-I00), the Instituto de Salud Carlos III (RD16/ 0011/0019) and by the Comunidad de Madrid (S2017/BMD3875). The Centro Nacional de Investigaciones Cardiovasculares Carlos III is supported by the Ministerio de Ciencia, Innovación y Universidades and the Pro Centro Nacional de Investigaciones Cardiovasculares Carlos III Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). A.C.L.-D. was the recipient of a Formación Personal Investigador fellowship from the Ministerio de Economı́a y Competitividad (BES-2013-064374).
dc.language.isoenges_ES
dc.publisherThe Company of Biologistses_ES
dc.relation.isversionofPublisher's versiones_ES
dc.titleAxial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis transcription factors and retinoic acid.es_ES
dc.typeArtículoes_ES
dc.identifier.pubmedID33298461es_ES
dc.format.volume148es_ES
dc.format.number1es_ES
dc.identifier.doi10.1242/dev.193813es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderComunidad de Madrides_ES
dc.contributor.funderFundación ProCNICes_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1242/dev.193813es_ES
dc.identifier.journalDevelopment (Cambridge, England)es_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Control Genético del Desarrollo y Regeneración de Órganoses_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Bioinformáticaes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PGC2018-096486-B-I00es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD16/0011/0019es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/S2017/BMD3875es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BES-2013-064374es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccesses_ES


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