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dc.contributor.authorGarcía-García, María Luz
dc.contributor.authorGonzalez-Carrasco, Ersilia
dc.contributor.authorBracamonte, Teresa
dc.contributor.authorMolinero, Mar 
dc.contributor.authorPozo Sánchez, Francisco 
dc.contributor.authorCasas, Inmaculada 
dc.contributor.authorCalvo, Cristina
dc.date.accessioned2021-03-22T16:14:25Z
dc.date.available2021-03-22T16:14:25Z
dc.date.issued2020
dc.identifier.citationJournal of Asthma and Allergy 2020:13 343–353es_ES
dc.identifier.issn1178-6965es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/12388
dc.description.abstractPremature birth is associated with increased susceptibility for viral infections and chronic airway morbidity. Preterm children, even moderate and late, may be at risk for short- and long-term respiratory morbidities. Our main goal was to compare the burden of two conditions, severe bronchiolitis and prematurity (early and moderate-late), on asthma development at 6-9 years. A retrospective cohort of all preterm (<37weeks gestational age) and full-term children hospitalized for bronchiolitis, with current age between 6 and 9 years, was created. A second cohort was made up of preterm children, without admission for bronchiolitis, randomly chosen from the hospital premature births database. Prevalence and risk factors for asthma were analysed. Parents completed the International Study of Asthma and Allergies in Childhood (ISAAC) Questionnaire for asthma symptoms for children 6-7 years. Lung function and aeroallergen sensitization were evaluated. Of the 480 selected children, 399 could be contacted and agreed to participate: 133 preterm and 114 full-term cases with admission for bronchiolitis and 146 preterm control children without admission for bronchiolitis. The frequency of current asthma at 6-9 years was higher in preterm cases (27%) compared with full-term-cases (15%) and preterm controls (14%) (p=0.04). Among hospitalized-bronchiolitis children, prematurity (p=0.04), rhinovirus infection (p=0.03), viral coinfection (p=0.04) and paternal asthma (p=0.003) were risk factors for asthma at 6-9 years. Among premature children, with and without bronchiolitis admission, the risk factors for asthma at 6-9 years were admission for bronchiolitis (p=0.03) and aeroallergen sensitisation (p=0.01). Moderate and late preterm children without admission for bronchiolitis showed similar prevalence of current asthma than full-term ones, previously admitted for bronchiolitis. Preterm birth is an important early life risk factor for asthma in childhood. The addition of other risk factors, such as severe bronchiolitis, especially by rhinovirus or viral coinfections, are associated with even higher risk for subsequent asthma.es_ES
dc.description.sponsorshipFIS (Fondo de Investigaciones Sanitarias) Este estudio ha sido financiado por FIS (Fondo de Investigaciones Sanitarias) Becas Nº: PI15CIII / 00028, PI18CIII / 00009.es_ES
dc.language.isoenges_ES
dc.publisherDove Medical Press es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/*
dc.subjectAsthmaes_ES
dc.subjectWheezinges_ES
dc.subjectPrematurityes_ES
dc.subjectBronchiolitises_ES
dc.subjectRhinoviruses_ES
dc.subjectRespiratory syncytial viruses_ES
dc.titleImpact of Prematurity and Severe Viral Bronchiolitis on Asthma Development at 6-9 Years.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial 3.0*
dc.identifier.pubmedID32982322es_ES
dc.format.volume13es_ES
dc.format.page343-353es_ES
dc.identifier.doi10.2147/JAA.S258447es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.2147/JAA.S258447es_ES
dc.identifier.journalJournal of asthma and allergyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15CIII/00028es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI18CIII/00009es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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