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dc.contributor.authorWagner, L
dc.contributor.authorStielow, J B
dc.contributor.authorde Hoog, G S
dc.contributor.authorBensch, K
dc.contributor.authorSchwartze, V U
dc.contributor.authorVoigt, K
dc.contributor.authorAlastruey-Izquierdo, Ana 
dc.contributor.authorKurzai, O
dc.contributor.authorWalther, G
dc.identifier.citationPersoonia . 2020 Jun;44:67-97.es_ES
dc.description.abstractMucor species are common soil fungi but also known as agents of human infections (mucormycosis) and used in food production and biotechnology. Mucor circinelloides is the Mucor species that is most frequently isolated from clinical sources. The taxonomy of Mucor circinelloides and its close relatives (Mucor circinelloides complex - MCC) is still based on morphology and mating behaviour. The aim of the present study was a revised taxonomy of the MCC using a polyphasic approach. Using a set of 100 strains molecular phylogenetic analysis of five markers (ITS, rpb1, tsr1, mcm7, and cfs, introduced here) were performed, combined with phenotypic studies, mating tests and the determination of the maximum growth temperatures. The multi-locus analyses revealed 16 phylogenetic species of which 14 showed distinct phenotypical traits and were recognised as discrete species. Five of these species are introduced as novel taxa: M. amethystinus sp. nov., M. atramentarius sp. nov., M. variicolumellatus sp. nov., M. pseudocircinelloides sp. nov., and M. pseudolusitanicus sp. nov. The former formae of M. circinelloides represent one or two separate species. In the MCC, the simple presence of well-shaped zygospores only indicates a close relation of both strains, but not necessarily conspecificity. Seven species of the MCC have been implemented in human infection: M. circinelloides, M. griseocyanus, M. janssenii, M. lusitanicus, M. ramosissimus, M. variicolumellatus, and M. velutinosus.es_ES
dc.description.sponsorshipWe kindly thank Jennifer Born for help with the soft-ware R. This project was funded by the Deutsche Forschungsgemeinschaft (DFG grant-No. WA 3518/1-1). Work in the National Reference Center for Invasive Fungal Infections NRZMyk is funded by the Robert-Koch Institut from funds provided by the Federal Ministry for Health (grant-no.: 1369-240).Molecular work performed at Westerdijk Institute (CBS-KNAW) was supportedby European Consortium of Microbial Resource Centres (EMbaRC) through funding of the European Community’s Seventh Framework Programme(FP7, 2007–2013), Research Infrastructures action, under grant agreement no. FP7-228310. Part of sequencing work in CBS was supported by Fonds Economische Structuurversterking (FES), Dutch Ministry of Education,Culture and Science grant BEK/BPR-2009/137964-U).es_ES
dc.publisherNaturalis Biodiversity Center & Centraalbureau voor Schimmelcultureses_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subjectmating testses_ES
dc.subjectmaximum growth temperaturees_ES
dc.subjectnew taxaes_ES
dc.subjectzygospore formationes_ES
dc.titleA new species concept for the clinically relevant Mucor circinelloides complex.es_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.contributor.funderDeutsche Forschungsgemeinschaft
dc.contributor.funderFederal Ministry for Health
dc.contributor.funderEuropean Consortium of Microbial Resource Centres (EMbaRC)
dc.contributor.funder7º Programa Marco - Comisión Europea
dc.contributor.funderDutch Ministry of Education,Culture and Science
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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