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dc.contributor.authorPadron-Monedero, Alicia 
dc.contributor.authorRodríguez-Artalejo, Fernando
dc.contributor.authorLopez-Garcia, Esther
dc.date.accessioned2021-03-03T12:32:16Z
dc.date.available2021-03-03T12:32:16Z
dc.date.issued2021-02-15
dc.identifier.citationSci Rep . 2021 Feb 15;11(1):3843.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/12093
dc.description.abstractPlasma fibrinogen predicts cardiovascular and nonvascular mortality. However, there is limited population-based evidence on the association between fibrinogen levels and dietary intakes of micronutrients possibly associated with inflammation status. Data were taken from the ENRICA study, conducted with 10,808 individuals representative of the population of Spain aged ≥ 18 years. Nutrient intake (vitamin A, carotenoids, vitamin B6, vitamin C, vitamin D, vitamin E, magnesium, selenium, zinc and iron) was estimated with a validated diet history, and plasma fibrinogen was measured under appropriate quality checks. Statistical analyses were performed with linear regression and adjusted for main confounders. The geometric means of fibrinogen (g/L) across increasing quintiles of nutrient intake were 3.22, 3.22, 3.22, 3.16, and 3.19 (p-trend = 0.030) for vitamin E; 3.23, 3.22, 3.20, 3.19, and 3.19 (p-trend = 0.047) for magnesium; and 3.24, 3.22, 3.19, 3.21, and 3.19 (p-trend = 0.050) for iron. These inverse associations were more marked in participants with abdominal obesity and aged ≥ 60 years, but lost statistical significance after adjustment for other nutrients. Although dietary intakes of vitamin E, magnesium and iron were inversely associated with fibrinogen levels, clinical implications of these findings are uncertain since these results were of very small magnitude and mostly explained by intake levels of other nutrients.es_ES
dc.description.sponsorshipThis work has been funded by State Secretary of R + D + I and FEDER/FSE FIS grants (F.R.A., grant 16/609 and 19/319; E.L.G., grant 16/1512); and the JPI HDHL-SALAMANDER project (F.R.A., grant APCIN 2016-145). The funders had no role in the design, analysis or writing of this workes_ES
dc.language.isoenges_ES
dc.publisherNature Researches_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleDietary micronutrients intake and plasma fibrinogen levels in the general adult population.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID33589702es_ES
dc.format.volume11es_ES
dc.format.number1es_ES
dc.format.page3843es_ES
dc.identifier.doi10.1038/s41598-021-83217-wes_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderFondo de Investigaciones Sanitariases_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2045-2322es_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-021-83217-wes_ES
dc.identifier.journalScientific reportses_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/16/609es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/19/319es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/16/1512es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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