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dc.contributor.authorGuerrero-Fernández de Alba, Inmaculada
dc.contributor.authorGimeno-Miguel, Antonio
dc.contributor.authorPoblador-Plou, Beatriz
dc.contributor.authorGimeno-Feliu, Luis Andrés
dc.contributor.authorIoakeim-Skoufa, Ignatios
dc.contributor.authorRojo-Martínez, Gemma
dc.contributor.authorForjaz, Maria João 
dc.contributor.authorPrados-Torres, Alexandra
dc.identifier.citationSci Rep. 2020 Nov 11;10(1):19583.es_ES
dc.description.abstractType 2 diabetes mellitus (T2D) is often accompanied by chronic diseases, including mental health problems. We aimed at studying mental health comorbidity prevalence in T2D patients and its association with T2D outcomes through a retrospective, observational study of individuals of the EpiChron Cohort (Aragón, Spain) with prevalent T2D in 2011 (n = 63,365). Participants were categorized as having or not mental health comorbidity (i.e., depression, anxiety, schizophrenia, and/or substance use disorder). We performed logistic regression models, controlled for age, sex and comorbidities, to analyse the likelihood of 4-year mortality, 1-year all-cause hospitalization, T2D-hospitalization, and emergency room visit. Mental health comorbidity was observed in 19% of patients. Depression was the most frequent condition, especially in women (20.7% vs. 7.57%). Mortality risk was higher in patients with mental health comorbidity (odds ratio 1.24; 95% confidence interval 1.16-1.31), especially in those with substance use disorder (2.18; 1.84-2.57) and schizophrenia (1.82; 1.50-2.21). Mental health comorbidity also increased the likelihood of all-cause hospitalization (1.16; 1.10-1.23), T2D-hospitalization (1.51; 1.18-1.93) and emergency room visit (1.26; 1.21-1.32). These results suggest that T2D healthcare management should include specific strategies for the early detection and treatment of mental health problems to reduce its impact on health outcomes.es_ES
dc.description.sponsorshipThis work was supported by Gobierno de Aragón [B01_20R] and the European Regional Development Fund “Construyendo Europa desde Aragón”. The authors sincerely thank Eva Giménez Labrador for her statistical support.es_ES
dc.publisherNature Publishing Group es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.titleAssociation between mental health comorbidity and health outcomes in type 2 diabetes mellitus patients.es_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderGobierno de Aragón (España)
dc.identifier.journalScientific reportses_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES

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