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dc.contributor.authorGonzalez-Jimenez, Irene
dc.contributor.authorLucio, Jose
dc.contributor.authorMenéndez-Fraga, Maria Dolores
dc.contributor.authorMellado, Emilia 
dc.contributor.authorPeláez, Teresa
dc.date.accessioned2021-01-26T09:26:38Z
dc.date.available2021-01-26T09:26:38Z
dc.date.issued2021-01-02
dc.identifier.citationJ Fungi (Basel) . 2021 Jan 2;7(1):22es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11676
dc.description.abstractAzole-resistant Aspergillus fumigatus is an emerging worldwide problem with increasing reports of therapy failure cases produced by resistant isolates. A case of azole-resistant A. fumigatus hospital colonization in a patient is reported here. Investigations of the hospital environment led to the recovery of A. fumigatus strains harboring the TR34/L98H and the G448S Cyp51A azole resistance mechanisms. Isolate genotyping showed that one strain from the environment was isogenic with the patient strains. These are the first environmental A. fumigatus azole resistant strains collected in a hospital in Spain; it supports the idea of the hospital environment as a source of dissemination and colonization/infection by azole resistant A. fumigatus in patients. The isolation of an azole-resistant strain from an azole-naïve patient is an interesting finding, suggesting that an effective analysis of clinical and environmental sources must be done to detect azole resistance in A. fumigatus. The emergence and spread of these resistance mechanisms in A. fumigatus is of major concern because it confers high resistance to voriconazole and is associated with treatment failure in patients with invasive aspergillosis.es_ES
dc.description.sponsorshipThis research was funded by Fondo de Investigacion Sanitaria (FIS PI18CIII/00045) and also by Plan Nacional de I+D+i 2013–2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía, Industria y Competitividad, Spanish Network for Research in Infectious Diseases (REIPI RD16/CIII/0004/0003), co-financed by European Development Regional Fund ERDF “A way to achieve Europe”, Operative program Intelligent Growth 2014–2020.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAspergillus fumigatuses_ES
dc.subjectazole resistance mechanismses_ES
dc.subjectcyp51Aes_ES
dc.subjecthospital environmentes_ES
dc.titleHospital Environment as a Source of Azole-Resistant Aspergillus fumigatus Strains with TR34/L98H and G448S Cyp51A Mutations.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID33401764es_ES
dc.format.volume7es_ES
dc.format.number1es_ES
dc.identifier.doi10.3390/jof7010022es_ES
dc.contributor.funderFondo de Investigaciones Sanitariases_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderRed Española de Investigación en Patología Infecciosaes_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2309-608Xes_ES
dc.relation.publisherversionhttps://doi.org/10.3390/jof7010022es_ES
dc.identifier.journalJournal of fungi (Basel, Switzerland)es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/FIS PI18CIII/00045es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/REIPI RD16/CIII/0004/0003es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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