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dc.contributor.authorDelgado-López, P D
dc.contributor.authorOrtega-Cubero, S
dc.contributor.authorCubo-Delgado, E
dc.contributor.authorGonzález-Bernal, JJ
dc.date.accessioned2021-01-15T09:13:03Z
dc.date.available2021-01-15T09:13:03Z
dc.date.issued2020-09-04
dc.identifier.citationNeurologia . 2020 Sep 4;S0213-4853(20)30225-5.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11619
dc.description.abstractNo formal indication currently exists for seizure prophylaxis in neurosurgical oncology patients. Neither have specific recommendations been made on the use of antiepileptic drugs (AED) in seizure-free patients with meningiomas scheduled for surgery. AEDs are generally prescribed on a discretionary basis, taking into consideration a range of clinical and radiological risk factors. We present a systematic review and meta-analysis exploring the effectiveness of antiepileptic prophylaxis in patients with meningioma and no history of seizures. We performed a systematic review of the PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, Embase, and clinicaltrials.gov databases. Of a total of 4368 studies initially identified, 12 were selected for extraction of data and qualitative analysis. Based on the clinical data presented, we were only able to include 6 studies in the meta-analysis. We performed heterogeneity studies, calculated a combined odds ratio, evaluated publication bias, and conducted a sensitivity analysis. AED prophylaxis in patients with meningioma and no history of seizures did not significantly reduce the incidence of post-operative seizures in comparison to controls (Mantel-Haenszel combined odds ratio, random effects model: 1.26 [95% confidence interval, 0.60-2.78]; 2041 patients). However, we are unable to establish a robust recommendation against this treatment due to the lack of prospective studies, the presence of selection bias in the studies reviewed, the likelihood of underestimation of seizure frequency during follow-up, and the strong influence of one study on the overall effect. Despite the limitations of this review, the results of the meta-analysis do not support the routine use of seizure prophylaxis in patients with meningioma and no history of seizures.es_ES
dc.language.isospaes_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAnalplásicoes_ES
dc.subjectAnaplasiaes_ES
dc.subjectAnti-seizurees_ES
dc.subjectAnticomiciales_ES
dc.subjectAntiepileptices_ES
dc.subjectAntiepilépticoes_ES
dc.subjectAtypicales_ES
dc.subjectAtípicoes_ES
dc.subjectMeningiomaes_ES
dc.subjectProfilaxises_ES
dc.subjectProphylaxises_ES
dc.titleProfilaxis antiepiléptica en meningiomas: revisión sistemática y metaanálisises_ES
dc.title.alternativeSeizure prophylaxis in meningiomas: A systematic review and meta-analysis.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID32896461es_ES
dc.identifier.doi10.1016/j.nrl.2020.06.014es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1578-1968
dc.relation.publisherversionhttps://doi.org/10.1016/j.nrl.2020.06.014es_ES
dc.identifier.journalNeurologia (Barcelona, Spain)es_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional