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dc.contributor.authorHong, Yun Soo
dc.contributor.authorRyu, Seungho
dc.contributor.authorChang, Yoosoo
dc.contributor.authorCaínzos-Achirica, Miguel
dc.contributor.authorKwon, Min-Jung
dc.contributor.authorZhao, Di
dc.contributor.authorShafi, Tariq
dc.contributor.authorLazo, Mariana
dc.contributor.authorPastor-Barriuso, Roberto 
dc.contributor.authorShin, Hocheol
dc.contributor.authorCho, Juhee
dc.contributor.authorGuallar, Eliseo
dc.identifier.citationBMC Nephrol . 2018 Dec 11;19(1):353. des_ES
dc.description.abstractThe effect of chronic hepatitis B virus (HBV) infection on the risk of chronic kidney disease (CKD) is controversial. We examined the prospective association between hepatitis B surface antigen (HBsAg) serology status and incident CKD in a large cohort of men and women. Cohort study of 299,913 adults free of CKD at baseline who underwent health screening exams between January 2002 and December 2016 in South Korea. Incident CKD was defined as the development of an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m2 and/or proteinuria. Over 1,673,701 person-years of follow-up, we observed 13,924 incident cases of CKD (3225 cases of eGFR < 60 ml/min/1.73m2 and 11,072 cases of proteinuria). In fully adjusted models comparing positive to negative HBsAg participants, the hazard ratio (HR, 95% confidence interval) for incident CKD was 1.11 (1.03-1.21; P = 0.01). The corresponding HR for incident proteinuria and for eGFR < 60 ml/min/1.73m2 were 1.23 (1.12-1.35; P <  0.001) and 0.89 (0.73-1.07; P = 0.21), respectively. The associations were similar across categories of liver enzyme levels at baseline. In this large cohort, HBsAg positive serology was associated with higher risk of incident CKD, and we provide novel evidence that this association was due to a higher incidence of proteinuria in HBsAg positive participants. Our study adds to the growing body of evidence suggesting that chronic HBV infection may be a contributor to the increasing incidence of CKD.es_ES
dc.publisherBioMed Central (BMC) es_ES
dc.subject.meshAdult es_ES
dc.subject.meshCohort Studies es_ES
dc.subject.meshFemale es_ES
dc.subject.meshFollow-Up Studies es_ES
dc.subject.meshHepatitis B, Chronic es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshRenal Insufficiency, Chronic es_ES
dc.subject.meshRepublic of Korea es_ES
dc.titleHepatitis B virus infection and development of chronic kidney disease: a cohort study.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.journalBMC nephrologyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.rights.accessRightsopen accesses_ES

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