Publication: Neuraminidase antibodies and H5N1: geographic-dependent influenza epidemiology could determine cross-protection against emerging strains.
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Publication date
2007-06
Authors
Bermejo-Martin, Jesus F
Kelvin, David J
Guan, Yi
Chen, Honglin
Perez-BreƱa, Pilar ISCIII 
Casas Flecha, Inmaculada ISCIII 
Arranz, Eduardo
de Lejarazu, Raul O
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Public Library of Science (PLOS)
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Abstract
We have read with great interest the work of Sandbulte et al. recently published in your journal [1]. In this article, the authors provide evidence for the existence of cross-immunity between the neuraminidase of H5N1 viruses and that of endemic human H1N1 viruses. Age may be an important determining factor in the development of cross-immunity: younger people, having a shorter history of H1N1 exposure, may be disproportionately susceptible to H5N1 infection.
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MeSH Terms
Animals Antibodies, Viral Disease Outbreaks Humans Influenza A Virus, H5N1 Subtype Influenza Vaccines Influenza, Human Mice Neuraminidase Orthomyxoviridae Infections
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Bibliographic citation
PLoS Med . 2007 Jun;4(6):e212. d
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journal article