Show simple item record

dc.contributor.authorOeo-Santos, Carmen
dc.contributor.authorNavas, Ana
dc.contributor.authorBenedé, Sara
dc.contributor.authorRuíz-León, Berta
dc.contributor.authorDíaz-Perales, Araceli
dc.contributor.authorVogel, Lothar
dc.contributor.authorMoreno-Aguilar, Carmen
dc.contributor.authorJurado, Aurora
dc.contributor.authorVillalba, Mayte
dc.contributor.authorBarderas Manchado, Rodrigo 
dc.date.accessioned2021-01-11T23:06:13Z
dc.date.available2021-01-11T23:06:13Z
dc.date.issued2020
dc.identifier.citationAllergy. 2020 Apr;75(4):798-807.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11596
dc.description.abstractOle e 7 is a nonspecific lipid transfer protein (nsLTP) from olive pollen, one of the main allergenic pollens worldwide. This allergenic nsLTP is responsible for severe symptoms in regions with high olive pollen exposure, where many Ole e 7-sensitized patients exhibit a co-sensitization to the peach nsLTP, Pru p 3. However, there is no evidence of cross-reactivity, which explains this observed co-sensitization. Therefore, the purpose of this study was to explore the relationship between Ole e 7 and Pru p 3. A total of 48 patients sensitized to Ole e 7 and/or Pru p 3 were included in the study. Specific IgE serum levels were measured by ImmunoCAP 250 and ELISA. Inhibition assays were performed to determine the existence of cross-reactivity between both nsLTPs. Allergic response was analyzed ex vivo (basophil activation test) and in vitro (RBL-2H3 mast cell model). Common IgG and IgE epitopes were identified between both allergens. IgE-binding inhibition was detected in Ole e 7-monosensitized patients using rPru p 3 as inhibitor, reaching inhibition values of 25 and 100%. Ex vivo and in vitro assays revealed a response against rPru p 3 in four (31%) Ole e 7-monosensitized patients. Our results suggest that Ole e 7 could play a new role as primary sensitizer in regions with high olive pollen exposure, leading to the peach nsLTP sensitization. This co-sensitization process would occur because of the cross-reactivity between Ole e 7 and Pru p 3 observed in some allergic patients.es_ES
dc.language.isoenges_ES
dc.publisherWiley es_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectCross-reactivityes_ES
dc.subjectNon-specific Lipid Transfer Proteines_ES
dc.subjectOlive pollinosises_ES
dc.subjectPeach allergyes_ES
dc.subjectPrimary sensitizationes_ES
dc.titleNew insights into the sensitization to nonspecific lipid transfer proteins from pollen and food: New role of allergen Ole e 7es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID31605380es_ES
dc.format.volume75es_ES
dc.format.number4es_ES
dc.format.page798-807es_ES
dc.identifier.doi10.1111/all.14086es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1398-9995
dc.relation.publisherversionhttps://doi.org/10.1111/all.14086es_ES
dc.identifier.journalAllergyes_ES
dc.repisalud.centroISCIII::Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC)es_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccesses_ES


Files in this item

Acceso Abierto
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Atribución-NoComercial-CompartirIgual 4.0 Internacional
This item is licensed under a: Atribución-NoComercial-CompartirIgual 4.0 Internacional