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dc.contributor.authorRubio-Ponce, Andrea 
dc.contributor.authorHidalgo, Andrés 
dc.contributor.authorBallesteros, Ivan 
dc.date.accessioned2020-12-29T09:42:09Z
dc.date.available2020-12-29T09:42:09Z
dc.date.issued2020-10-07
dc.identifier.citationCurr Opin Immunol. 2020; 68:41-47es_ES
dc.identifier.issn0952-7915
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11567
dc.description.abstractRecent high-dimensional technologies have enabled the characterization of heterogeneity in the neutrophil compartment at an unprecedented resolution. In this review, we discuss the emerging notion of heterogeneity within the neutrophil pool, and provide a detailed account of evolving concepts in the field. We place special focus on neutrophil differentiation in the bone marrow and plasticity in tissues, describe the limitations that arise when exploring neutrophil heterogeneity using single-cell analyses, and suggest state-of-the-art alternatives to improve their characterization. Finally, we propose strategies arising from these new concepts that may allow us to bridle neutrophil plasticity towards therapeutic benefit.es_ES
dc.description.sponsorshipThis study was supported by grants RTI2018-095497-B-I00 from the Ministerio de Ciencia e Innovacion (MICINN), HR17_00527 from Fundacio´n La Caixa, and by Transatlantic network of excellence (TNE-18CVD04) form the Leducq Foundation to A. H. A.R-P. is supported by fellowship (BES-2016-076635) from MICINN, I. B. is supported by fellowship MSCA-IF-EF-748381 and the CNIC is supported by the MICINN and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MICINN award SEV-2015-0505).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleHow to bridle a neutrophil.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID33038850es_ES
dc.format.volume68es_ES
dc.format.page41-47es_ES
dc.identifier.doi10.1016/j.coi.2020.08.003es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderFundación La Caixaes_ES
dc.contributor.funderLeducq Foundationes_ES
dc.contributor.funderFundación ProCNICes_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.coi.2020.08.003es_ES
dc.identifier.journalCurrent opinion in immunologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmunees_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RTI2018-095497-B-I00es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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