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dc.contributor.authorBallesteros, Ivan 
dc.contributor.authorRubio-Ponce, Andrea 
dc.contributor.authorGenua, Marco
dc.contributor.authorLusito, Eleonora
dc.contributor.authorKwok, Immanuel
dc.contributor.authorFernández-Calvo, Gabriel
dc.contributor.authorKhoyratty, Tariq E
dc.contributor.authorvan Grinsven, Erinke
dc.contributor.authorGonzalez-Hernández, Sara 
dc.contributor.authorNicolás-Ávila, José Ángel
dc.contributor.authorVicanolo, Tommaso
dc.contributor.authorMaccataio, Antonio
dc.contributor.authorBenguria, Alberto 
dc.contributor.authorLi, Jackson LiangYao 
dc.contributor.authorAdrover, Jose M 
dc.contributor.authorAroca-Crevillen, Alejandra 
dc.contributor.authorQuintana, Juan A. 
dc.contributor.authorMartin-Salamanca, Sandra 
dc.contributor.authorMayo, Francisco
dc.contributor.authorAscher, Stefanie
dc.contributor.authorBarbiera, Giulia
dc.contributor.authorSoehnlein, Oliver
dc.contributor.authorGunzer, Matthias
dc.contributor.authorGinhoux, Florent
dc.contributor.authorSanchez-Cabo, Fatima 
dc.contributor.authorNistal-Villán, Estanislao
dc.contributor.authorSchulz, Christian
dc.contributor.authorDopazo, Ana 
dc.contributor.authorReinhardt, Christoph
dc.contributor.authorUdalova, Irina A
dc.contributor.authorNg, Lai Guan
dc.contributor.authorOstuni, Renato
dc.contributor.authorHidalgo, Andrés 
dc.date.accessioned2020-12-29T09:02:20Z
dc.date.available2020-12-29T09:02:20Z
dc.date.issued2020-11-25
dc.identifier.citationCell. 2020; 183(5):1282-1297es_ES
dc.identifier.issn0092-8674
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11566
dc.description.abstractClassically considered short-lived and purely defensive leukocytes, neutrophils are unique in their fast and moldable response to stimulation. This plastic behavior may underlie variable and even antagonistic functions during inflammation or cancer, yet the full spectrum of neutrophil properties as they enter healthy tissues remains unexplored. Using a new model to track neutrophil fates, we found short but variable lifetimes across multiple tissues. Through analysis of the receptor, transcriptional, and chromatin accessibility landscapes, we identify varying neutrophil states and assign non-canonical functions, including vascular repair and hematopoietic homeostasis. Accordingly, depletion of neutrophils compromised angiogenesis during early age, genotoxic injury, and viral infection, and impaired hematopoietic recovery after irradiation. Neutrophils acquired these properties in target tissues, a process that, in the lungs, occurred in CXCL12-rich areas and relied on CXCR4. Our results reveal that tissues co-opt neutrophils en route for elimination to induce programs that support their physiological demands.es_ES
dc.description.sponsorshipThis study was supported byIntramural grants from the Severo Ochoa program (IGP-SO), a grant from Fundacio la Marato de TV3 (120/C/2015-20153032), grant SAF2015-65607-R fromMinisterio de Ciencia e Innovacion (MICINN) with co-funding by Fondo Eu-ropeo de Desarrollo Regional (FEDER), RTI2018-095497-B-I00 from MICINN,HR17_00527 from Fundacion La Caixa, and Transatlantic Network of Excel-lence (TNE-18CVD04) from the Leducq Foundation to A.H. I.B. is supportedby fellowship MSCA-IF-EF-748381 and EMBO short-term fellowship 8261.A.R.-P. is supported by a fellowship (BES-2016-076635) and J.A.N.-A. byfellowship SVP-2014-068595 from MICINN. R.O. is supported by ERC startinggrant 759532, Italian Telethon Foundation SR-Tiget grant award F04, ItalianMoH grant GR-201602362156, AIRC MFAG 20247, Cariplo Foundation grant2015-0990, and the EU Infect-ERA 126. C.S. is supported by the SFB 1123,project A07, as well as by the DZHK (German Centre for Cardiovascular Research) and the BMBF (German Ministry of Education and Research) grant81Z0600204. L.G.N. is supported by SIgN core funding from A*STAR. The CNIC is supported by the MICINN and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (MICINN award SEV-2015-0505). G.F.-C. issupported by the Spanish Ministerio de Ciencia e Innovacio ́n (grantPID2019-110895RB-100) and Junta de Comunidades de Castilla-La Mancha(grant SBPLY/19/180501/000211). C.R. received funding from the BoehingerIngelheim Foundation (consortium grant ‘‘Novel and Neglected CardiovascularRisk Factors’’) and German Federal Ministry of Education and Research(BMBF 01EO1503) and is a Fellow of the Gutenberg Research College (GFK)at the Johannes Gutenberg-University Mainzes_ES
dc.language.isoenges_ES
dc.publisherCell Presses_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleCo-option of Neutrophil Fates by Tissue Environments.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID33098771es_ES
dc.format.volume183es_ES
dc.format.number5es_ES
dc.format.page1282-1297.e18es_ES
dc.identifier.doi10.1016/j.cell.2020.10.003es_ES
dc.contributor.funderFundació La Maratóes_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderFundación La Caixaes_ES
dc.contributor.funderLeducq Foundationes_ES
dc.contributor.funderEuropean Research Counciles_ES
dc.contributor.funderItalian Telethon Foundationes_ES
dc.contributor.funderCariplo Foundationes_ES
dc.contributor.funderDZHK - German Centre for Cardiovascular Researches_ES
dc.contributor.funderFundación ProCNICes_ES
dc.contributor.funderJunta de Comunidades de Castilla-La Manchaes_ES
dc.contributor.funderBoehingerIngelheim Foundationes_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.cell.2020.10.003es_ES
dc.identifier.journalCelles_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmunees_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Bioinformáticaes_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Genómicaes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-65607-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PID2019-110895RB-100es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RTI2018-095497-B-I00es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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