Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/11500
Hepatitis C prevalence in injecting drug users in Europe, 1990-2007: impact of study recruitment setting
Rondy, M | Wiessing, L | Hutchinson, S J | Matheï, C | Mathis, F | Mravcik, V | Norden, L | Rosińska, M | Scutelniciuc, O | Suligoi, B | Vallejo-Ruiz de Leon, Fernando ISCIII | Van Veen, M | Kretzschmar, M
Epidemiol Infect. 2013 Mar;141(3):563-72.
Monitoring injecting drug users' (IDUs) health is challenging because IDUs form a difficult to reach population. We examined the impact of recruitment setting on hepatitis C prevalence. Individual datasets from 12 studies were merged. Predictors of HCV positivity were sought through a multilevel analysis using a mixed-effects logistic model, with study identifier as random intercept. HCV prevalence ranged from 21% to 86% across the studies. Overall, HCV prevalence was higher in IDUs recruited in drug treatment centres compared to those recruited in low-threshold settings (74% and 42%, respectively, P < 0·001). Recruitment setting remained significantly associated with HCV prevalence after adjustment for duration of injecting and recent injection (adjusted odds ratio 0·7, 95% confidence interval 0·6-0·8, P = 0·05). Recruitment setting may have an impact on HCV prevalence estimates of IDUs in Europe. Assessing the impact of mixed recruitment strategies, including respondent-driven sampling, on HCV prevalence estimates, would be valuable.
Needle-Exchange Programs | Patient Selection | Substance Abuse Treatment Centers | Adult | Europe | Female | Hepatitis C | Humans | Male | Prevalence | Research Design | Selection Bias | Seroepidemiologic Studies | Substance Abuse, Intravenous
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