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dc.contributor.authorOlías-Molero, A I
dc.contributor.authorMoreno-Iruela, Inmaculada 
dc.contributor.authorCorral, María J
dc.contributor.authorJiménez-Antón, M D
dc.contributor.authorDay, M J
dc.contributor.authorDomínguez, M
dc.contributor.authorAlunda, José M
dc.date.accessioned2020-12-04T07:34:42Z
dc.date.available2020-12-04T07:34:42Z
dc.date.issued2020
dc.identifier.citationSci Rep. 2020 Nov 2;10(1):18826es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11497
dc.description.abstractLeishmania infantum is the etiological agent of zoonotic visceral leishmaniasis. In endemic areas, canine infections are considered the main source of infection for human populations. Therefore, any control of human leishmaniasis must include the control of canine infections. Chemotherapy of leishmaniasis is inadequate and canine immunoprophylaxis has important limitations. Reports on the response of infected dogs are abundant but no clear picture of immune events has emerged. To shed some light on these shortcomings the specific IgG subclass response was followed in 20 Beagle dogs experimentally infected with L. infantum using monoclonal antibodies (MAb) specific for canine IgG1, IgG2, IgG3 and IgG4, along with ELISA and flow cytometry. Results showed that parasitic infection elicits a general response of all IgG subclasses, with a predominant IgG1 response and without any evidence of IgG1/IgG2 dichotomy. These findings suggest that the inconsistent results reported previously could be related to the lack of specific reagents and not to the actual differences in the immune response of infected animals. Differential IgG subclass reactivity in ELISA and cytometry and the analysis of the reacting antigens could facilitate the diagnosis and prognosis of the disease and provide a useful tool for adequate therapeutics and vaccine development against leishmaniasis.es_ES
dc.description.sponsorshipThis project has received partial funding from the European Union Seventh Framework Programme for research, technological development and demonstration under grant agreement n° 603240 (NMTrypI – New Medicines for Trypanosomatidic Infections).es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Group es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleInfection of dogs by Leishmania infantum elicits a general response of IgG subclasses.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID33139752es_ES
dc.format.volume10es_ES
dc.format.number1es_ES
dc.format.page18826es_ES
dc.identifier.doi10.1038/s41598-020-75569-6es_ES
dc.contributor.funderEuropean Union
dc.description.peerreviewedes_ES
dc.identifier.e-issn2045-2322
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-020-75569-6es_ES
dc.identifier.journalScientific reportses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/603240es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución 4.0 Internacional
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