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dc.contributor.authorMachado, Ausenda
dc.contributor.authorKislaya, Irina
dc.contributor.authorLarrauri, Amparo 
dc.contributor.authorMatias Dias, Carlos
dc.contributor.authorNunes, Baltazar
dc.identifier.citationBMC Public Health . 2019 Dec 16;19(1):1690.es_ES
dc.description.abstractAll aged individuals with a chronic condition and those with 65 and more years are at increased risk of severe influenza post-infection complications. There is limited research on cases averted by the yearly vaccination programs in high-risk individuals. The objective was to estimate the impact of trivalent seasonal influenza vaccination on averted hospitalizations and death among the high-risk population in Portugal. The impact of trivalent seasonal influenza vaccination was estimated using vaccine coverage, vaccine effectiveness and the number of influenza-related hospitalizations and deaths. The number of averted events (NAE), prevented fraction (PF) and number needed to vaccinate (NVN) were estimated for seasons 2014/15 to 2016/17. The vaccination strategy averted on average approximately 1833 hospitalizations and 383 deaths per season. Highest NAE was observed in the ≥65 years population (85% of hospitalizations and 95% deaths) and in the 2016/17 season (1957 hospitalizations and 439 deaths). On average, seasonal vaccination prevented 21% of hospitalizations in the population aged 65 and more, and 18.5% in the population with chronic conditions. The vaccination also prevented 29% and 19.5% of deaths in each group of the high-risk population. It would be needed to vaccinate 3360 high-risk individuals, to prevent one hospitalization and 60,471 high-risk individuals to prevent one death. The yearly influenza vaccination campaigns had a sustained positive benefit for the high-risk population, reducing hospitalizations and deaths. These results can support public health plans toward increased vaccine coverage in high-risk groups.es_ES
dc.description.sponsorshipActivities related to individuals aged 65 and more years were supported by European Commission Horizon 2020 programme [grant agreement No 634446]. The funding body had no role in the design, collection, analysis, and interpretation of data and or in writing the manuscript.es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subject.meshImmunization Programs es_ES
dc.subject.meshAged es_ES
dc.subject.meshHospitalization es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInfluenza Vaccines es_ES
dc.subject.meshInfluenza, Humanes_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshPortugal es_ES
dc.subject.meshProgram Evaluation es_ES
dc.subject.meshRisk Assessment es_ES
dc.subject.meshSeasons es_ES
dc.subject.meshSeverity of Illness Index es_ES
dc.titleImpact of national influenza vaccination strategy in severe influenza outcomes among the high-risk Portuguese population.es_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderEuropean Commissiones_ES
dc.identifier.journalBMC public healthes_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES

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Atribución 4.0 Internacional
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