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dc.contributor.authorKafatos, G
dc.contributor.authorAndrews, N
dc.contributor.authorMcConway, K J
dc.contributor.authorAnastassopoulou, C
dc.contributor.authorBarbara, C
dc.contributor.authorDe Ory, Fernando de 
dc.contributor.authorJohansen, K
dc.contributor.authorMossong, J
dc.contributor.authorProsenc, K
dc.contributor.authorVranckx, R
dc.contributor.authorNardone, A
dc.contributor.authorPebody, R
dc.contributor.authorFarrington, P
dc.date.accessioned2020-12-01T07:28:19Z
dc.date.available2020-12-01T07:28:19Z
dc.date.issued2015-08
dc.identifier.citationEpidemiol Infect. 2015 Aug;143(11):2269-78.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11473
dc.description.abstractThe aim of the European Sero-Epidemiology Network 2 (ESEN2) project was to estimate age-specific seroprevalence for a number of vaccine-preventable diseases in Europe. To achieve this serosurveys were collected by 22 national laboratories. To adjust for a variety of laboratory methods and assays, all quantitative results were transformed to a reference laboratory's units and were then classified as positive or negative to obtain age-specific seroprevalence. The aim of this study was to assess the value of standardization by comparing the crude and standardized seroprevalence estimates. Seroprevalence was estimated for measles, mumps, rubella, diphtheria, varicella zoster and hepatitis A virus (HAV) and compared before and after serological results had been standardized. The results showed that if no such adjustment had taken place, seroprevalence would have differed by an average of 3·2% (95% bootstrap interval 2·9-3·6) although this percentage varied substantially by antigen. These differences were as high as 16% for some serosurveys (HAV) which means that standardization could have a considerable impact on seroprevalence estimates and should be considered when comparing serosurveys performed in different laboratories using different assay methods.es_ES
dc.description.sponsorshipWe thank all the ESEN2 members who contributed to the collection and testing of the serological samples included in this paper. The ESEN2 project was funded by the European Commission (contract number QLK2-CT-2000–00542), national governments and other national funding sources.es_ES
dc.language.isoenges_ES
dc.publisherCambridge University Press es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectESEN2es_ES
dc.subjectSeroprevalencees_ES
dc.subjectSerosurveyes_ES
dc.subjectStandardizationes_ES
dc.subjectVaccinationes_ES
dc.subject.meshAdolescent es_ES
dc.subject.meshAdult es_ES
dc.subject.meshChickenpox es_ES
dc.subject.meshChild es_ES
dc.subject.meshChild, Preschool es_ES
dc.subject.meshDiphtheria es_ES
dc.subject.meshDiphtheria Toxoid es_ES
dc.subject.meshEurope es_ES
dc.subject.meshHepatitis A es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInfant es_ES
dc.subject.meshMeasles es_ES
dc.subject.meshMumps es_ES
dc.subject.meshReference Standards es_ES
dc.subject.meshRubella es_ES
dc.subject.meshSeroepidemiologic Studies es_ES
dc.subject.meshViral Vaccines es_ES
dc.subject.meshYoung Adult es_ES
dc.titleEstimating seroprevalence of vaccine-preventable infections: is it worth standardizing the serological outcomes to adjust for different assays and laboratories?es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID25420586es_ES
dc.format.volume143es_ES
dc.format.number11es_ES
dc.format.page2269-78es_ES
dc.identifier.doi10.1017/S095026881400301Xes_ES
dc.contributor.funderEuropean Commission es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1469-4409
dc.relation.publisherversionhttps://doi.org/10.1017/S095026881400301Xes_ES
dc.identifier.journalEpidemiology and infectiones_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EU/QLK2-CT-2000–00542es_ES
dc.rights.accessRightsopen accesses_ES


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