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dc.contributor.authorMate-Cano, Irene 
dc.contributor.authorAlvaro-Meca, Alejandro
dc.contributor.authorRyan, Pablo
dc.contributor.authorResino, Salvador 
dc.contributor.authorBriz, Verónica 
dc.date.accessioned2020-11-13T13:10:22Z
dc.date.available2020-11-13T13:10:22Z
dc.date.issued2020-05
dc.identifier.citationEur J Intern Med . 2020 May;75:84-92.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11337
dc.description.abstractAnalysis the epidemiological trends of hospital admissions, intra-hospital deaths, and costs related to chronic hepatitis C (CHC) taking into account four major clinical stages [compensated cirrhosis (CC), end-stage liver disease (ESLD), hepatocellular carcinoma (HCC), and liver transplantation (LT)] in Spain. Retrospective study in patients with chronic hepatitis C and a hospital admission in the Spanish Minimum Basic Data Set from 2000 to 2015. Outcome variables were admission, death, length of hospital stay and costs. A total of 868,523 hospital admissions with CHC (25.5% CC, 25.3% ESLD, 8.6% HCC, and 2.5% LT) were identified. Overall rates of admission and mortality increased from 2000-2003 to 2004-2007, but after 2008, these rates stabilized and/or decreased. An upward trend was found for hospitalization percentage in CC (from 22.3% to 30%; p < 0.001), ESLD (from 23.9% to 27.1%; p < 0.001), HCC (from 7.4% to 11%; p < 0.001), and LT (from 0.07% to 0.10%; p = 0.003). An upward trend was also found for case fatality rate, except in ESLD (p = 0.944). Gender and age influenced the evolution of hospitalization rates and mortality differently. The length of hospital stay showed a significant downward trend in all strata analyzed (p < 0.001). Cost per patient had a significant upward trend (p < 0.001), except in LT, and a decrease from 2008-2011 to 2012-2015 in CC (p = 0.025), HCC (p < 0.001), and LT (p = 0.050) was found. The initial upward trend of the disease burden in CHC has changed from 2000 to 2015 in Spain, improving in many parameters after 2004-2007, particularly in the 2012-2015 calendar period.es_ES
dc.description.sponsorshipThis work has been supported by grantsfrom “Instituto de Salud Carlos III” (PI15CIII/00031, PI18CIII/00047). The study was also funded by the RD16CIII/0002/0002 project as part of the Plan Nacional R + D + I and cofoundedby ISCIII-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional(FEDER).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChronic hepatitis Ces_ES
dc.subjectCirrhosises_ES
dc.subjecthepatocarcinomaes_ES
dc.subjectliver transplantationes_ES
dc.subjectEnd stage liver diseasees_ES
dc.subjectHospital admissionses_ES
dc.subjectICD9CM codeses_ES
dc.subjectMortalityes_ES
dc.titleEpidemiological trend of hepatitis C-related liver events in Spain (2000-2015): A nationwide population-based study.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID32143898es_ES
dc.format.volume75es_ES
dc.format.page84-92es_ES
dc.identifier.doi10.1016/j.ejim.2020.02.002es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIII
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)
dc.description.peerreviewedes_ES
dc.identifier.e-issn1879-0828
dc.relation.publisherversionhttps://doi.org/10.1016/j.ejim.2020.02.002es_ES
dc.identifier.journalEuropean journal of internal medicinees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15CIII/00031es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI18CIII/00047es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD16CIII/0002/0002es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional