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dc.contributor.authorBueno, Hector 
dc.contributor.authorRossello, Xavier 
dc.contributor.authorPocock, Stuart 
dc.contributor.authorVan de Werf, Frans
dc.contributor.authorChin, Chee Tang
dc.contributor.authorDanchin, Nicolas
dc.contributor.authorLee, Stephen W-L
dc.contributor.authorMedina, Jesús
dc.contributor.authorVega, Ana
dc.contributor.authorHuo, Yong
dc.identifier.citationClin Res Cardiol. 2018; 107(9):836-844es_ES
dc.description.abstractTherapeutic variability not explained by patient clinical characteristics is a potential source of avoidable morbidity and mortality. We aimed to explore regional variability in the management and mortality of patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS). 11,931 NSTE-ACS hospital survivors enrolled in two prospective registries: EPICOR [5625 patients, 555 hospitals, 20 countries in Europe (E) and Latin America (LA), September 2010-March 2011] and EPICOR Asia (6306 patients, 218 hospitals, 8 countries, June 2011-May 2012) were compared among eight pre-defined regions: Northern E (NE), Southern E (SE), Eastern E (EE); Latin America (LA); China (CN), India (IN), South-East Asia (SA), and South Korea, Hong Kong and Singapore (KS). Patient characteristics differed between regions: mean age (lowest 59 years, IN; highest 65.9 years, SE), diabetes (21.4% NE; 35.5% IN) and smoking (32% NE; 62% IN). Variations in dual antiplatelet therapy at discharge (lowest 83.1%, IN; highest 97.5%, SA), coronary angiography (53.9% SA; 90.6% KS), percutaneous coronary intervention (35.8% SA; 78.6% KS) and coronary artery bypass graft (0.7% KS; 5.7% NE) were observed. Unadjusted 2-year mortality ranged between 3.8% in KS and 11.7% in SE. Two-year, risk-adjusted mortality rates ranged between 5.1% (95% confidence interval 2.9-7.3%) in KS to 10.5% (8.3-12.7%) in LA. Wide regional variations in patient features, hospital care, coronary revascularization and post-discharge mortality are present among patients hospitalized for NSTE-ACS. Focused regional interventions to improve the quality of care for NSTE-ACS patients are still needed.es_ES
dc.publisherSpringer es_ES
dc.subject.meshDisease Management es_ES
dc.subject.meshElectrocardiography es_ES
dc.subject.meshPatient Discharge es_ES
dc.subject.meshRegistries es_ES
dc.subject.meshAcute Coronary Syndrome es_ES
dc.subject.meshAged es_ES
dc.subject.meshEurope es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshLatin America es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshProspective Studies es_ES
dc.subject.meshRisk Assessment es_ES
dc.subject.meshRisk Factors es_ES
dc.titleRegional variations in hospital management and post-discharge mortality in patients with non-ST-segment elevation acute coronary syndrome.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.contributor.funderFundación AstraZeneca 
dc.identifier.journalClinical research in cardiology : official journal of the German Cardiac Societyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Investigación Cardiovascular Traslacional Multidisciplinariaes_ES
dc.rights.accessRightsopen accesses_ES

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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