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dc.contributor.authorKordowitzki, Paweł
dc.contributor.authorLópez de Silanes, Isabel
dc.contributor.authorGuío-Carrión, Ana
dc.contributor.authorBlasco, MA 
dc.date.accessioned2020-10-06T07:41:49Z
dc.date.available2020-10-06T07:41:49Z
dc.date.issued2020-08-29
dc.identifier.citationAging (Albany NY). 2020 ;12(16):15906-15917.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11092
dc.description.abstractTelomeres are transcribed into long non-coding RNAs known as Telomeric Repeat-Containing RNA (TERRA). They have been shown to be essential regulators of telomeres and to act as epigenomic modulators at extra-telomeric sites. However the role of TERRA during early embryonic development has never been investigated. Here, we show that TERRA is expressed in murine and bovine early development following a wave pattern. It starts at 4-cell stage, reaching a maximum at the 16-cell followed by a decline at the morula and blastocyst stages. Moreover, TERRA expression is not affected by increasing oocyte donor age whereas telomere length does. This indicates that TERRA expression is independent of the telomere length in early development. Our findings anticipate an essential role of TERRA in early stages of development and this might be useful in the future for a better understanding of age related female infertility.es_ES
dc.description.sponsorshipDr P. Kordowitzki was supported by KNOW consortium (Poland MS&HE, Decision No. 05-1/KNOW2/2015) and by a special statutory fund of DRI&P IAR&FR PAS in Olsztyn. The support of Sagrario Ortega and co-workers is gratefully acknowledged. Research in the Blasco Lab is funded by the Spanish Ministry of Economy and Competitiveness Projects (SAF2013-45111-R and SAF2015-72455-EXP), the Comunidad de Madrid Project (S2017/BMD-3770), the World Cancer Research (WCR) Project (16-1177), and the Fundacion Botin (Spain).es_ES
dc.language.isoenges_ES
dc.publisherImpact Journals es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectGERM-CELLSes_ES
dc.subjectDELAYED CHILDBEARINGes_ES
dc.subjectTERRAes_ES
dc.subjectTRANSCRIPTIONes_ES
dc.subjectHOMEOSTASISes_ES
dc.subjectACTIVATIONes_ES
dc.subjectCLEARANCEes_ES
dc.subjectLENGTHes_ES
dc.subjectRATESes_ES
dc.subjectEZH2es_ES
dc.titleDynamics of telomeric repeat-containing RNA expression in early embryonic cleavage stages with regards to maternal agees_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID32860669es_ES
dc.format.volume12es_ES
dc.format.number16es_ES
dc.format.page15906-15917es_ES
dc.identifier.doi10.18632/aging.103922es_ES
dc.contributor.funderKNOW consortium (Poland MSHE)
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderComunidad de Madrid 
dc.contributor.funderWorldwide Cancer Research (WCR)
dc.contributor.funderFundacion Botin (Spain)
dc.description.peerreviewedes_ES
dc.identifier.e-issn1945-4589es_ES
dc.relation.publisherversionhttps://doi.org/10.18632/aging.103922.es_ES
dc.identifier.journalAginges_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Telómeros y Telomerasaes_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/SAF2013-45111-Res_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/SAF2015-72455-EXPes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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