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dc.contributor.authorDominguez-Molina, Beatriz
dc.contributor.authorTarancon-Diez, Laura
dc.contributor.authorMilanés-Guisado, Yusnelkis
dc.contributor.authorGenebat, Miguel
dc.contributor.authorRodriguez, Carmen
dc.contributor.authorResino, Salvador 
dc.contributor.authorGonzalez-García, Juan
dc.contributor.authorRallón, Norma
dc.contributor.authorLeón, Agathe
dc.contributor.authorGarcía, Felipe
dc.contributor.authorDel Romero, Jorge
dc.contributor.authorViciana, Pompeyo
dc.contributor.authorLopez-Cortes, Luis F
dc.contributor.authorLeal, Manuel
dc.contributor.authorRuiz-Mateos, Ezequiel
dc.contributor.authorCasado, Concepcion 
dc.contributor.authorPernas, Maria 
dc.contributor.authorLopez-Galindez, Luis Cecilio 
dc.contributor.authorBenito, José M
dc.identifier.citationJ Int AIDS Soc . 2020 Sep;23(9):e25607.es_ES
dc.description.abstractHIV-controllers have the ability to spontaneously maintain viraemia at low or undetectable levels in the absence of antiretroviral treatment. Furthermore, HIV-controllers seem to have a superior capacity to spontaneously clear hepatitis C virus (HCV) compared to non HIV-controllers. Some of these subjects eventually lose HIV-controller status (transient controllers), whereas some HIV-controllers show a persistent natural HIV control (persistent controllers). We aimed to analyse whether persistent controllers have superior capacity to spontaneously clear HCV compared to transient controllers. We recruited HIV-controllers from January 1981 up to October 2016 with available antibodies to HCV (anti-HCV) data (n = 744). Factors associated with HIV spontaneous control in relation to HCV status were analysed in persistent and transient HIV-controllers with anti-HCV positive (n = 202 and n = 138 respectively) in comparison with 1700 HCV positive non HIV-controllers recruited from January 1981 up to March 2018, bivariate and multivariate analyses, following a logistic regression model, were applied. In addition, the factors related to the loss and time to lose HIV-controller status were explored (n = 744) using Log rank test and Kaplan-Meier curves, in this case the multivariate analysis consisted in a Cox regression model. A higher frequency of HCV spontaneous clearance was found in persistent HIV-controllers (25.5%) compared to non-controllers (10.2%). After adjusting for potential confounders, as sex, age, HIV transmission risk, CD4+ T-cell nadir and time of follow-up, HCV clearance was independently associated with persistent HIV spontaneous control (p = 0.002; OR (95% CI) = 2.573 (1.428 to 4.633)), but not with transient spontaneous control (p = 0.119; 1.589 (0.888 to 2.845)). Furthermore, persistent HIV-controllers were more likely to spontaneously clear the HCV in comparison with transient controllers (p = 0.027; 0.377 (0.159 to 0.893). Finally, not to lose or lengthen the time of losing this control was independently associated with HCV spontaneous clearance (p = 0.010; 0.503 (0.297 to 0.850). This study shows an association between spontaneous persistent HIV-control and HCV spontaneous clearance. The study findings support the idea of preserved immune mechanisms in persistent HIV control implicated in HCV spontaneous clearance. These results highlight persistent HIV-controllers but not transient controllers as a good model of functional HIV cure.es_ES
dc.description.sponsorshipThis work was supported by the Instituto de Salud Carlos III (research contracts CPII014/00025 to E.R.‐M., and FI14/00431 to L.T.‐D. and research projects PI12/02283, PI16/00684, PI19/01127 to E.R.‐M.) and Red Temática de Investigación Cooperativa en SIDA (Projects RD12/0017/0029, RD12/0017/0031, and RD16/0025/0020 and RD16/0025/0013), which is included in the Acción Estratégica en Salud, Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica 2008 to 2011 and 2013 to 2016, Instituto de Salud Carlos III, Fondos FEDER. E.R.‐M. was supported by Consejería de Salud y Bienestar Social of Junta de Andalucía through the Nicolás Monardes program (C‐0032/17), N Rallón is a Miguel Servet investigator from the Spanish Carlos III Institute of Health (ISCIII), grant CP14/00198, Madrid, Spain and B.D.M. received a grant from The Spanish Ministry of Education (FPU13/02451). Work in CL‐G’s laboratory was supported by grants SAF (2010 to 17226) and (2016‐77894‐R) from MINECO (Spain) and FIS (PI 13/02269, ISCIII) and in part by the RIS‐RETIC grants RD06/006/0036 and RD12/0017/0028 funded by the ISC III‐FEDER. MP has a contract of RIS‐RETIC RD12/0017/0036.es_ES
dc.publisherWiley Open Accesses_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subject.meshHCV spontaneous clearancees_ES
dc.subject.meshHIV es_ES
dc.titlePersistent HIV-controllers are more prone to spontaneously clear HCV: a retrospective cohort study.es_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderRed Temática Cooperativa de Investigación en Sida (España)es_ES
dc.contributor.funderGobierno de Andalucíaes_ES
dc.contributor.funderMinisterio de Educación (España)es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderRedes Tematicas de Investigacion Cooperativa en Salud (España)es_ES
dc.identifier.journalJournal of the International AIDS Societyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/CPII014 / 00025es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/FI14 / 00431es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI12 / 02283es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI16 / 00684es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI19 / 01127es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RD12 / 0017/0029es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/D12 / 0017/0031es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RD16 / 0025/0020es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RD16 / 0025/0013es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/C ‐ 0032/17es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/CP14 / 00198es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/FPU13 / 02451es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/2010 a 17226es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/2016‐77894 ‐ Res_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI 13/02269, ISCIIIes_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RETIC RD06 / 006/003es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RD12 / 0017/0028es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RETIC RD12 / 0017/0036es_ES

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