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dc.contributor.authorDominguez-Molina, Beatriz
dc.contributor.authorTarancon-Diez, Laura
dc.contributor.authorMilanés-Guisado, Yusnelkis
dc.contributor.authorGenebat, Miguel
dc.contributor.authorRodriguez, Carmen
dc.contributor.authorResino, Salvador 
dc.contributor.authorGonzalez-García, Juan
dc.contributor.authorRallón, Norma
dc.contributor.authorLeón, Agathe
dc.contributor.authorGarcía, Felipe
dc.contributor.authorDel Romero, Jorge
dc.contributor.authorViciana, Pompeyo
dc.contributor.authorLopez-Cortes, Luis F
dc.contributor.authorLeal, Manuel
dc.contributor.authorRuiz-Mateos, Ezequiel
dc.contributor.authorCasado, Concepcion 
dc.contributor.authorPernas, Maria 
dc.contributor.authorLopez-Galindez, Luis Cecilio 
dc.contributor.authorBenito, José Miguel
dc.date.accessioned2020-09-29T09:08:49Z
dc.date.available2020-09-29T09:08:49Z
dc.date.issued2020-09
dc.identifier.citationJ Int AIDS Soc. 2020 Sep;23(9):e25607.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11081
dc.description.abstractHIV-controllers have the ability to spontaneously maintain viraemia at low or undetectable levels in the absence of antiretroviral treatment. Furthermore, HIV-controllers seem to have a superior capacity to spontaneously clear hepatitis C virus (HCV) compared to non HIV-controllers. Some of these subjects eventually lose HIV-controller status (transient controllers), whereas some HIV-controllers show a persistent natural HIV control (persistent controllers). We aimed to analyse whether persistent controllers have superior capacity to spontaneously clear HCV compared to transient controllers. We recruited HIV-controllers from January 1981 up to October 2016 with available antibodies to HCV (anti-HCV) data (n = 744). Factors associated with HIV spontaneous control in relation to HCV status were analysed in persistent and transient HIV-controllers with anti-HCV positive (n = 202 and n = 138 respectively) in comparison with 1700 HCV positive non HIV-controllers recruited from January 1981 up to March 2018, bivariate and multivariate analyses, following a logistic regression model, were applied. In addition, the factors related to the loss and time to lose HIV-controller status were explored (n = 744) using Log rank test and Kaplan-Meier curves, in this case the multivariate analysis consisted in a Cox regression model. A higher frequency of HCV spontaneous clearance was found in persistent HIV-controllers (25.5%) compared to non-controllers (10.2%). After adjusting for potential confounders, as sex, age, HIV transmission risk, CD4+ T-cell nadir and time of follow-up, HCV clearance was independently associated with persistent HIV spontaneous control (p = 0.002; OR (95% CI) = 2.573 (1.428 to 4.633)), but not with transient spontaneous control (p = 0.119; 1.589 (0.888 to 2.845)). Furthermore, persistent HIV-controllers were more likely to spontaneously clear the HCV in comparison with transient controllers (p = 0.027; 0.377 (0.159 to 0.893). Finally, not to lose or lengthen the time of losing this control was independently associated with HCV spontaneous clearance (p = 0.010; 0.503 (0.297 to 0.850). This study shows an association between spontaneous persistent HIV-control and HCV spontaneous clearance. The study findings support the idea of preserved immune mechanisms in persistent HIV control implicated in HCV spontaneous clearance. These results highlight persistent HIV-controllers but not transient controllers as a good model of functional HIV cure.es_ES
dc.description.sponsorshipThis work was supported by the Instituto de Salud Carlos III (research contracts CPII014/00025 to E.R.‐M., and FI14/00431 to L.T.‐D. and research projects PI12/02283, PI16/00684, PI19/01127 to E.R.‐M.) and Red Temática de Investigación Cooperativa en SIDA (Projects RD12/0017/0029, RD12/0017/0031, and RD16/0025/0020 and RD16/0025/0013), which is included in the Acción Estratégica en Salud, Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica 2008 to 2011 and 2013 to 2016, Instituto de Salud Carlos III, Fondos FEDER. E.R.‐M. was supported by Consejería de Salud y Bienestar Social of Junta de Andalucía through the Nicolás Monardes program (C‐0032/17), N Rallón is a Miguel Servet investigator from the Spanish Carlos III Institute of Health (ISCIII), grant CP14/00198, Madrid, Spain and B.D.M. received a grant from The Spanish Ministry of Education (FPU13/02451). Work in CL‐G’s laboratory was supported by grants SAF (2010 to 17226) and (2016‐77894‐R) from MINECO (Spain) and FIS (PI 13/02269, ISCIII) and in part by the RIS‐RETIC grants RD06/006/0036 and RD12/0017/0028 funded by the ISC III‐FEDER. MP has a contract of RIS‐RETIC RD12/0017/0036.es_ES
dc.language.isoenges_ES
dc.publisherWiley es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHIVes_ES
dc.subjectHCVes_ES
dc.subjectHIV-controllerses_ES
dc.subjectPersistentes_ES
dc.subjectTransientes_ES
dc.subjectHCV spontaneous clearancees_ES
dc.titlePersistent HIV-controllers are more prone to spontaneously clear HCV: a retrospective cohort studyen
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID32909370es_ES
dc.format.volume23es_ES
dc.format.number9es_ES
dc.format.pagee25607es_ES
dc.identifier.doi10.1002/jia2.25607es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderRed de Investigación Cooperativa en Investigación en Sida (España) 
dc.contributor.funderRegional Government of Andalusia (España) 
dc.contributor.funderMinisterio de Educación (España) 
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.contributor.funderRETICS-Sida (RIS-ISCIII) (España) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1758-2652es_ES
dc.relation.publisherversionhttps://doi.org/10.1002/jia2.25607es_ES
dc.identifier.journalJournal of the International AIDS Societyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.relation.projectFECYTinfo:eu_repo/grantAgreement/ES/RD12/0017/0029
dc.relation.projectFECYTinfo:eu_repo/grantAgreement/ES/RD12/0017/0031
dc.relation.projectFECYTinfo:eu_repo/grantAgreement/ES/RD16/0025/0020
dc.relation.projectFECYTinfo:eu_repo/grantAgreement/ES/RD16/0025/0013
dc.relation.projectFECYTinfo:eu_repo/grantAgreement/ES/FPU13/02451
dc.relation.projectFECYTinfo:eu_repo/grantAgreement/ES/SAF2016‐77894‐R
dc.relation.projectFECYTinfo:eu_repo/grantAgreement/ES/SAF2010‐17226
dc.relation.projectFISinfo:eu_repo/grantAgreement/ES/CPII014/00025
dc.relation.projectFISinfo:eu_repo/grantAgreement/ES/FI14/00431
dc.relation.projectFISinfo:eu_repo/grantAgreement/ES/PI12/02283
dc.relation.projectFISinfo:eu_repo/grantAgreement/ES/PI16/00684
dc.relation.projectFISinfo:eu_repo/grantAgreement/ES/PI19/01127
dc.relation.projectFISinfo:eu_repo/grantAgreement/ES/PI13/02269
dc.relation.projectFISinfo:eu_repo/grantAgreement/ES/CP14/00198
dc.relation.projectFISinfo:eu_repo/grantAgreement/ES/RD06/006/0036
dc.relation.projectFISinfo:eu_repo/grantAgreement/ES/RD12/0017/0028
dc.relation.projectFISinfo:eu_repo/grantAgreement/ES/RD12/0017/0036


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Atribución 4.0 Internacional
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