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dc.contributor.authorBär, Christian
dc.contributor.authorChatterjee, Shambhabi
dc.contributor.authorFalcão Pires, Inês
dc.contributor.authorRodrigues, Patrícia
dc.contributor.authorSluijter, Joost P G
dc.contributor.authorBoon, Reinier A
dc.contributor.authorNevado, Rosa M 
dc.contributor.authorAndres, Vicente 
dc.contributor.authorSansonetti, Marida
dc.contributor.authorde Windt, Leon
dc.contributor.authorCiccarelli, Michele
dc.contributor.authorHamdani, Nazha
dc.contributor.authorHeymans, Stephane
dc.contributor.authorFiguinha Videira, Raquel
dc.contributor.authorTocchetti, Carlo G
dc.contributor.authorGiacca, Mauro
dc.contributor.authorZacchigna, Serena
dc.contributor.authorEngelhardt, Stefan
dc.contributor.authorDimmeler, Stefanie
dc.contributor.authorMadonna, Rosalinda
dc.contributor.authorThum, Thomas
dc.identifier.citationCardiovasc Res. 2020; 116(11):1805-1819es_ES
dc.description.abstractVast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs among others. Contrary to previous opinions that most of these RNAs are non-functional molecules, they are now recognized as critical regulators of many physiological and pathological processes including those of the cardiovascular system. The discovery of functional ncRNAs has opened up new research avenues aiming at understanding ncRNA-related disease mechanisms as well as exploiting them as novel therapeutics in cardiovascular therapy. In this review, we give an update on the current progress in ncRNA research, particularly focusing on cardiovascular physiological and disease processes, which are under current investigation at the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. This includes a range of topics such as extracellular vesicle-mediated communication, neurohormonal regulation, inflammation, cardiac remodelling, cardio-oncology as well as cardiac development and regeneration, collectively highlighting the wide-spread involvement and importance of ncRNAs in the cardiovascular system.es_ES
dc.description.sponsorshipTT and CB were supported by Deutsche Forschungsgemeinschaft, DFG (TRR267) and the ERANet CVD (JTC2016 project EXPERT to TT and JTC2018 project INNOVATION to CB). CGT was supported by a “Federico II University/Ricerca di Ateneo” grant. IFP is supported by Fundo Europeu de Desenvolvimento Regional (FEDER) through Compete 2020 – Programa Operacional Competitividade E Internacionalização (POCI), the project NETDIAMOND (POCI-01-0145-FEDER-016385), supported by European Structural And Investment Funds, Lisbon’s regional operational program 2020. PR is funded by FCT (SFRH/BD/96026/2013). RM was supported by a Cardio-Oncology grants from Incyte s.r.l. and funds from Ministero dell’Istruzione, Università e Ricerca Scientifica (549901_2020_Madonna: Ateneo). NH was supported by Deutsche Forschungsgemeinschaft, DFG (HA7512/2-1). J.P.G.S. was supported by the Project EVICARE (No. 725229) of the European Research Council (ERC). VA’s laboratory received support from the Instituto de Salud Carlos III (ISCIII) (grant AC16/00091, as member of the ERA-CVD JCT2016 EXPERT Network, European Union's Horizon 2020 Framework Programme), with co-funding from the European Regional Development Fund (ERDF/FEDER, “Una manera de hacer Europa”). RMN is supported by the Ministerio de Educación, Cultura y Deporte (predoctoral contract FPU16/05027). The CNIC is supported by the Spanish Ministerio de Ciencia e Innovación (MCI), the ISCIII, and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505).es_ES
dc.publisherEuropean Society of Cardiology (ESC) es_ES
dc.publisherOxford University Press es_ES
dc.titleNon-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.contributor.funderDeutsche Forschungsgemeinschaft (Alemania) 
dc.contributor.funderUniversity of Naples Federico II (Italia) 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderEuropean Structural and Investment Funds
dc.contributor.funderMinistero dell Istruzione, dell Universita e della Ricerca (Italia) 
dc.contributor.funderEuropean Research Council 
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderUnión Europea 
dc.contributor.funderMinisterio de Ciencia e Innovación (España) 
dc.contributor.funderFundación ProCNIC 
dc.identifier.journalCardiovascular researches_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Fisiopatología Cardiovascular Molecular y Genéticaes_ES
dc.rights.accessRightsembargoed accesses_ES

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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