Show simple item record

dc.contributor.authorFuentes, Pedro
dc.contributor.authorSesé, Marta
dc.contributor.authorGuijarro, Pedro J
dc.contributor.authorEmperador, Marta
dc.contributor.authorSánchez-Redondo, Sara
dc.contributor.authorHümmer, Stefan
dc.contributor.authorRamón Y Cajal, Santiago
dc.contributor.authorPeinado Selgas, Hector 
dc.date.accessioned2020-09-01T10:20:28Z
dc.date.available2020-09-01T10:20:28Z
dc.date.issued2020-08-26
dc.identifier.citationNat Commun. 2020;11(1):4261.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10913
dc.description.abstractMetastasis, the spread of malignant cells from a primary tumour to distant sites, causes 90% of cancer-related deaths. The integrin ITGB3 has been previously described to play an essential role in breast cancer metastasis, but the precise mechanisms remain undefined. We have now uncovered essential and thus far unknown roles of ITGB3 in vesicle uptake. The functional requirement for ITGB3 derives from its interactions with heparan sulfate proteoglycans (HSPGs) and the process of integrin endocytosis, allowing the capture of extracellular vesicles and their endocytosis-mediated internalization. Key for the function of ITGB3 is the interaction and activation of focal adhesion kinase (FAK), which is required for endocytosis of these vesicles. Thus, ITGB3 has a central role in intracellular communication via extracellular vesicles, proposed to be critical for cancer metastasis.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Group es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID32848136es_ES
dc.format.volume11es_ES
dc.format.number1es_ES
dc.format.page4261es_ES
dc.identifier.doi10.1038/s41467-020-18081-9es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2041-1723es_ES
dc.relation.publisherversionhttps://doi.org/10.18632/10.1038/s41467-020-18081-9.es_ES
dc.identifier.journalNature communicationses_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Microambiente y Metástasises_ES
dc.rights.accessRightsopen accesses_ES


Files in this item

Acceso Abierto
Thumbnail
Acceso Abierto
Thumbnail
Acceso Abierto
Thumbnail
Acceso Abierto
Thumbnail
Acceso Abierto
Thumbnail
Acceso Abierto

This item appears in the following Collection(s)

Show simple item record

Atribución-NoComercial-CompartirIgual 4.0 Internacional
This item is licensed under a: Atribución-NoComercial-CompartirIgual 4.0 Internacional