Mostrar el registro sencillo del ítem

dc.contributor.authorPérez-García, Felipe
dc.contributor.authorSoria, Susana
dc.contributor.authorJorge-Monjas, Pablo
dc.contributor.authorGómez-Sánchez, Esther
dc.contributor.authorHeredia-Rodríguez, María
dc.contributor.authorGómez-Pesquera, Estefanía
dc.contributor.authorMartínez-Paz, Pedro
dc.contributor.authorTamayo, Eduardo
dc.contributor.authorResino, Salvador 
dc.contributor.authorFernandez-Rodriguez, Amanda 
dc.contributor.authorJimenez-Sousa, Maria Angeles 
dc.date.accessioned2020-08-10T08:33:16Z
dc.date.available2020-08-10T08:33:16Z
dc.date.issued2020
dc.identifier.citationFront Med (Lausanne) . 2020 May 14;7:186.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10878
dc.description.abstractInterferon lambda 3 (IFNL3, previously called IL-28B) is a cytokine with effects against viral and bacterial pathogens. We aimed to analyze the IFNL3 rs12980275 SNP in patients who underwent major surgery, in order to establish its relationship with susceptibility to septic shock and septic shock-related death in these patients. We performed a case-control study on 376 patients to establish the association between IFNL3 rs12980275 SNP and the susceptibility to develop septic shock. Besides, we performed a longitudinal study among 172 septic shock patients using survival analysis with one censoring point of 28-days mortality. The IFNL3 rs12980275 polymorphism was genotyped by Agena Bioscience's MassARRAY platform. IFNL3 rs12980275 polymorphism was not associated with higher susceptibility to infection and septic shock development. Regarding survival analysis, the Kaplan-Meier analysis showed that patients with IFNL3 rs12980275 AA genotype had higher survival than patients with GG genotype (p = 0.003). The Cox regression analysis adjusted by the most relevant clinical and epidemiological characteristics showed that the GG genotype (recessive model) and the presence of the G allele (additive model) were associated with higher risk of death [adjusted hazard ratio (aHR) = 2.15, p = 0.034; aHR = 1.50, p = 0.030, respectively]. In conclusion, IFNL3 rs12980275 polymorphism was associated with septic shock-related death in patients who underwent major surgery. The A allele was linked to protection, and the G allele was associated with an increased risk of death. This is a first preliminary study that suggests for the first time a role of IFNL3 polymorphisms in the prognosis of septic shock.es_ES
dc.description.sponsorshipThis work has been supported by grants given by Instituto de Salud Carlos III (grant numbers PI15/01451 to ET), Gerencia de Salud, Consejería de Sanidad, Junta de Castilla y Leon (grant number GRS 463/A/10 and 773/A/13 to ET), and PFIZER (grant number CT25-ESP01-01 to SR). MJ-S and AF-R are supported by Instituto de Salud Carlos III (grant numbers CP17CIII/00007 and CP14CIII/00010, respectively).es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Media es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshIFNL3es_ES
dc.subject.meshSNPes_ES
dc.subject.meshMajor surgeryes_ES
dc.subject.meshrs12980275es_ES
dc.subject.meshSepsis es_ES
dc.subject.meshseptic shockes_ES
dc.subject.meshSurvival es_ES
dc.titleIFNL3 rs12980275 Polymorphism Predicts Septic Shock-Related Death in Patients Undergoing Major Surgery: A Retrospective Studyes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID32478085es_ES
dc.format.volume7es_ES
dc.identifier.doi10.3389/fmed.2020.00186es_ES
dc.contributor.funderPfizer 
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderJunta de Castilla y León (España) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn2296-858Xes_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fmed.2020.00186es_ES
dc.identifier.journalFrontiers in Medicinees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI15/01451es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/463/A/10es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/773/A/13es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/CT25-ESP01-01es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/CP17CIII/00007es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/CP14CIII/00010es_ES
dc.rights.accessRightsopen accesses_ES


Ficheros en el ítem

Acceso Abierto
Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional