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dc.contributor.authorMirones, Isabel
dc.contributor.authorMariñas-Pardo, Luis
dc.contributor.authorMelen, Gustavo J
dc.contributor.authorRamírez, Manuel
dc.contributor.authorRodriguez-Milla, Miguel A 
dc.contributor.authorCubillo, Isabel 
dc.contributor.authorGarcia-Castro, Javier 
dc.date.accessioned2020-07-07T20:36:32Z
dc.date.available2020-07-07T20:36:32Z
dc.date.issued2012-08
dc.identifier.citationInt J Mol Med . 2012 Aug;30(2):365-73.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10696
dc.description.abstractNeuroblastoma (NB) is one of the most common pediatric solid tumors and, like most human cancers, is char-acterized by a broad variety of genomic alterations. Although mesenchymal stem cells (MSCs) are known to interact with cancer cells, the relationship between MSCs and metastatic NB cancer cells in bone marrow (BM) is unknown. To obtain genetic evidence about this interaction, we isolated ΒΜ-derived MSCs from children with NB and compared their global expression patterns with MSCs obtained from normal pediatric donors, using the Agilent 44K microarrays. Significance analysis of microarray results with a false discovery rate (FDR) <5% identified 496 differentially expressed genes showing either a 2-fold upregulation or downregulation between both groups of samples. Comparison of gene ontology categories of differ-entially expressed genes revealed the upregulation of genes categorized as ‘neurological system process’, ‘cell adhesion’, ‘apoptosis’, ‘cell surface receptor linked signal transduction’, ‘intrinsic to membrane’ and ‘extracellular region’. Among the downregulated genes, several immunology-related terms were the most abundant. These findings provide preliminary genetic evidence of the interaction between MSCs and NB cancer cells in ΒΜ as well as identify relevant biological processes potentially altered in MSCs in response to NBes_ES
dc.description.sponsorshipThis study was supported by grants from the Fondo de Investigaciones Sanitarias (FIS; PI05/2217 and PI08/0029 to J.G.C.), MICINN (PLE2009-0115) and the Madrid Regional Government (S-BIO-0204-2006 and P2010/BMD-2420) in Spain. The experiments were approved by the appropriate committees.es_ES
dc.language.isoenges_ES
dc.publisherSpandidos Publications es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshGene Expression es_ES
dc.subject.meshBone Marrow Cells es_ES
dc.subject.meshCluster Analysis es_ES
dc.subject.meshComputational Biology es_ES
dc.subject.meshGene Expression Profiling es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMesenchymal Stem Cells es_ES
dc.subject.meshNeuroblastoma es_ES
dc.titleEnrichment of neural-related genes in human mesenchymal stem cells from neuroblastoma patients.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID22641458es_ES
dc.format.volume30es_ES
dc.format.number2es_ES
dc.format.page365-73es_ES
dc.identifier.doi10.3892/ijmm.2012.1008es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderComunidad de Madrid (España) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1791-244Xes_ES
dc.relation.publisherversionhttps://doi.org/10.3892/ijmm.2012.1008es_ES
dc.identifier.journalInternational journal of molecular medicinees_ES
dc.repisalud.centroISCIII::Instituto de Investigación de Enfermedades Rarases_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/FIS; PI05/2217es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI08/0029es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PLE2009-0115es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/S-BIO-0204-2006es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/P2010/BMD-2420es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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