Mostrar el registro sencillo del ítem
dc.contributor.author | Mirones, Isabel | |
dc.contributor.author | Mariñas-Pardo, Luis | |
dc.contributor.author | Melen, Gustavo J | |
dc.contributor.author | Ramírez, Manuel | |
dc.contributor.author | Rodriguez-Milla, Miguel A | |
dc.contributor.author | Cubillo, Isabel | |
dc.contributor.author | Garcia-Castro, Javier | |
dc.date.accessioned | 2020-07-07T20:36:32Z | |
dc.date.available | 2020-07-07T20:36:32Z | |
dc.date.issued | 2012-08 | |
dc.identifier.citation | Int J Mol Med . 2012 Aug;30(2):365-73. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/10696 | |
dc.description.abstract | Neuroblastoma (NB) is one of the most common pediatric solid tumors and, like most human cancers, is char-acterized by a broad variety of genomic alterations. Although mesenchymal stem cells (MSCs) are known to interact with cancer cells, the relationship between MSCs and metastatic NB cancer cells in bone marrow (BM) is unknown. To obtain genetic evidence about this interaction, we isolated ΒΜ-derived MSCs from children with NB and compared their global expression patterns with MSCs obtained from normal pediatric donors, using the Agilent 44K microarrays. Significance analysis of microarray results with a false discovery rate (FDR) <5% identified 496 differentially expressed genes showing either a 2-fold upregulation or downregulation between both groups of samples. Comparison of gene ontology categories of differ-entially expressed genes revealed the upregulation of genes categorized as ‘neurological system process’, ‘cell adhesion’, ‘apoptosis’, ‘cell surface receptor linked signal transduction’, ‘intrinsic to membrane’ and ‘extracellular region’. Among the downregulated genes, several immunology-related terms were the most abundant. These findings provide preliminary genetic evidence of the interaction between MSCs and NB cancer cells in ΒΜ as well as identify relevant biological processes potentially altered in MSCs in response to NB | es_ES |
dc.description.sponsorship | This study was supported by grants from the Fondo de Investigaciones Sanitarias (FIS; PI05/2217 and PI08/0029 to J.G.C.), MICINN (PLE2009-0115) and the Madrid Regional Government (S-BIO-0204-2006 and P2010/BMD-2420) in Spain. The experiments were approved by the appropriate committees. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Spandidos Publications | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject.mesh | Gene Expression | es_ES |
dc.subject.mesh | Bone Marrow Cells | es_ES |
dc.subject.mesh | Cluster Analysis | es_ES |
dc.subject.mesh | Computational Biology | es_ES |
dc.subject.mesh | Gene Expression Profiling | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Mesenchymal Stem Cells | es_ES |
dc.subject.mesh | Neuroblastoma | es_ES |
dc.title | Enrichment of neural-related genes in human mesenchymal stem cells from neuroblastoma patients. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-NoComercial-CompartirIgual 4.0 Internacional | * |
dc.identifier.pubmedID | 22641458 | es_ES |
dc.format.volume | 30 | es_ES |
dc.format.number | 2 | es_ES |
dc.format.page | 365-73 | es_ES |
dc.identifier.doi | 10.3892/ijmm.2012.1008 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1791-244X | es_ES |
dc.relation.publisherversion | https://doi.org/10.3892/ijmm.2012.1008 | es_ES |
dc.identifier.journal | International journal of molecular medicine | es_ES |
dc.repisalud.centro | ISCIII::Instituto de Investigación de Enfermedades Raras | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/FIS; PI05/2217 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/PI08/0029 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/PLE2009-0115 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/S-BIO-0204-2006 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/P2010/BMD-2420 | es_ES |
dc.rights.accessRights | open access | es_ES |