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dc.contributor.author | Cussó, Lorena | |
dc.contributor.author | Mirones, Isabel | |
dc.contributor.author | Peña-Zalbidea, Santiago | |
dc.contributor.author | García-Vázquez, Verónica | |
dc.contributor.author | Desco, Manuel | |
dc.contributor.author | Garcia-Castro, Javier | |
dc.date.accessioned | 2020-07-07T19:39:40Z | |
dc.date.available | 2020-07-07T19:39:40Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Mol Imaging . 2014;13. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/10694 | |
dc.description.abstract | Homing is an inherent, complex, multistep process performed by cells such as human bone marrow mesenchymal stem cells (hMSCs) to travel from a distant location to inflamed or damaged tissue and tumors. This ability of hMSCs has been exploited as a tumor-targeting strategy in cell-based cancer therapy. The purpose of this study was to investigate the applicability of 111In-oxine for tracking hMSCs in vivo by combining single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). 111In-labeled hMSCs (106 cells) were infused intraperitoneally in neuroblastoma-bearing mice, whereas a control group received a dose of free 111In-oxine. SPECT and MRI studies were performed 24 and 48 hours afterwards. Initially, the images showed similar activity in the abdomen in both controls and hMSC-injected animals. In general, abdominal activity decreases at 48 hours. hMSC-injected animals showed increased uptake in the tumor area at 48 hours, whereas the control group showed a low level of activity at 24 hours, which decreased at 48 hours. In conclusion, tracking 111In-labeled hMSCs combining SPECT and MRI is feasible and may be transferable to clinical research. The multimodal combination is essential to ensure appropriate interpretation of the images. | es_ES |
dc.description.sponsorship | Financial disclosure of authors: This work was funded in part by grants from Ministerio de Economía y Competitividad (PLE2009-0115), Red Tematica de Investigacion Cooperativa en Cancer (RTICC/ISCIII; RD12/0036/0027), the Madrid Regional Government (S-BIO-0204-2006–MesenCAM and P2010/BMD-2420-CellCAM), and the Ministerio de Ciencia e Innovación (CEN-20101014 and TEC-2010-21619-C04-01). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | SAGE Publishing | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Cell Line, Tumor | es_ES |
dc.subject.mesh | Cells, Cultured | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Magnetic Resonance Imaging | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Mesenchymal Stem Cell Transplantation | es_ES |
dc.subject.mesh | Mesenchymal Stem Cells | es_ES |
dc.subject.mesh | Mice | es_ES |
dc.subject.mesh | Mice, SCID | es_ES |
dc.subject.mesh | Neoplasm Transplantation | es_ES |
dc.subject.mesh | Neuroblastoma | es_ES |
dc.subject.mesh | Organometallic Compounds | es_ES |
dc.subject.mesh | Oxyquinoline | es_ES |
dc.subject.mesh | Tomography, Emission-Computed, Single-Photon | es_ES |
dc.title | Combination of single-photon emission computed tomography and magnetic resonance imaging to track 111in-oxine-labeled human mesenchymal stem cells in neuroblastoma-bearing mice. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 25248941 | |
dc.format.volume | 13 | es_ES |
dc.identifier.doi | 10.2310/7290.2014.00033 | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Red Temática de Investigación Cooperativa en Cáncer (RTICC) (España) | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1536-0121 | es_ES |
dc.relation.publisherversion | https://doi.org/10.2310/7290.2014.00033 | es_ES |
dc.identifier.journal | Molecular imaging | es_ES |
dc.repisalud.centro | ISCIII::Instituto de Investigación de Enfermedades Raras | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/PLE2009-0115 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/RD12/0036/0027 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/S-BIO-0204-2006–MesenCAM | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/and P2010/BMD-2420-CellCAM | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/CEN-20101014 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/TEC-2010-21619-C04-01 | es_ES |
dc.rights.accessRights | open access | es_ES |