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dc.contributor.authorCussó, Lorena
dc.contributor.authorMirones, Isabel
dc.contributor.authorPeña-Zalbidea, Santiago
dc.contributor.authorGarcía-Vázquez, Verónica
dc.contributor.authorDesco, Manuel
dc.contributor.authorGarcia-Castro, Javier
dc.identifier.citationMol Imaging . 2014;13.es_ES
dc.description.abstractHoming is an inherent, complex, multistep process performed by cells such as human bone marrow mesenchymal stem cells (hMSCs) to travel from a distant location to inflamed or damaged tissue and tumors. This ability of hMSCs has been exploited as a tumor-targeting strategy in cell-based cancer therapy. The purpose of this study was to investigate the applicability of 111In-oxine for tracking hMSCs in vivo by combining single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). 111In-labeled hMSCs (106 cells) were infused intraperitoneally in neuroblastoma-bearing mice, whereas a control group received a dose of free 111In-oxine. SPECT and MRI studies were performed 24 and 48 hours afterwards. Initially, the images showed similar activity in the abdomen in both controls and hMSC-injected animals. In general, abdominal activity decreases at 48 hours. hMSC-injected animals showed increased uptake in the tumor area at 48 hours, whereas the control group showed a low level of activity at 24 hours, which decreased at 48 hours. In conclusion, tracking 111In-labeled hMSCs combining SPECT and MRI is feasible and may be transferable to clinical research. The multimodal combination is essential to ensure appropriate interpretation of the images.es_ES
dc.description.sponsorshipFinancial disclosure of authors: This work was funded in part by grants from Ministerio de Economía y Competitividad (PLE2009-0115), Red Tematica de Investigacion Cooperativa en Cancer (RTICC/ISCIII; RD12/0036/0027), the Madrid Regional Government (S-BIO-0204-2006–MesenCAM and P2010/BMD-2420-CellCAM), and the Ministerio de Ciencia e Innovación (CEN-20101014 and TEC-2010-21619-C04-01).es_ES
dc.publisherSAGE Publicationses_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subject.meshAnimals es_ES
dc.subject.meshCell Line, Tumor es_ES
dc.subject.meshCells, Cultured es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMagnetic Resonance Imaging es_ES
dc.subject.meshMale es_ES
dc.subject.meshMesenchymal Stem Cell Transplantation es_ES
dc.subject.meshMesenchymal Stem Cells es_ES
dc.subject.meshMice es_ES
dc.subject.meshMice, SCID es_ES
dc.subject.meshNeoplasm Transplantation es_ES
dc.subject.meshNeuroblastoma es_ES
dc.subject.meshOrganometallic Compounds es_ES
dc.subject.meshOxyquinoline es_ES
dc.subject.meshTomography, Emission-Computed, Single-Photon es_ES
dc.titleCombination of single-photon emission computed tomography and magnetic resonance imaging to track 111in-oxine-labeled human mesenchymal stem cells in neuroblastoma-bearing mice.es_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderRed Temática de Investigación Cooperativa en Cáncer (España)es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderComunidad de Madrides_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.identifier.journalMolecular imaginges_ES
dc.repisalud.centroISCIII::Instituto de Investigación de Enfermedades Rarases_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/and P2010/BMD-2420-CellCAMes_ES

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Atribución 4.0 Internacional
This item is licensed under a: Atribución 4.0 Internacional