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dc.contributor.authorCarro, Eva
dc.contributor.authorBartolomé, Fernando
dc.contributor.authorBermejo-Pareja, Félix
dc.contributor.authorVillarejo-Galende, Alberto
dc.contributor.authorMolina, José Antonio
dc.contributor.authorOrtiz, Pablo
dc.contributor.authorCalero, Miguel 
dc.contributor.authorRábano, Alberto
dc.contributor.authorCantero, José Luis
dc.contributor.authorOrive, Gorka
dc.date.accessioned2020-06-29T17:07:23Z
dc.date.available2020-06-29T17:07:23Z
dc.date.issued2017
dc.identifier.citationAlzheimers Dement (Amst) . 2017 May 26;8:131-138.es_ES
dc.identifier.issn2352-8729es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10608
dc.description.abstractThe Alzheimer's disease (AD) process is likely initiated many years before clinical onset. Biomarkers of preclinical disease are critical for the development of disease-modifying or even preventative therapies. Current biomarkers for early disease, including cerebrospinal fluid tau and amyloid β (Aβ) levels, structural and functional magnetic resonance imaging, and the use of brain amyloid imaging, are limited because they are very invasive or expensive. Noninvasive biomarkers may be a more accessible alternative, but none can currently detect preclinical AD with the required sensitivity and specificity. Here, we show a novel, straight-forward, and noninvasive approach for assessment of early stages of cognitive decline. Salivary samples from cases of amnestic mild cognitive impairment (aMCI) and AD, and neurology controls were analyzed. We have discovered and validated a new single saliva biomarker, lactoferrin, which in our cross-sectional investigation perfectly discriminates clinically diagnosed aMCI and AD patients from a cognitively healthy control group. The accuracy for AD diagnosis shown by salivary lactoferrin was greater than that obtained from core cerebrospinal fluid (CSF) biomarkers, including total tau and CSF Aβ42. Furthermore, salivary lactoferrin can be used for population screening and for identifying those underdiagnosed subjects with very early stages of mild cognitive impairment and AD. This biomarker may offer new insights in the early diagnostics for AD.es_ES
dc.description.sponsorshipThe authors are grateful to Juan Carlos del Castillo who participated in the promotion of this study. The authors specially thank Raquel Cobos, Consuelo Pascual, Desiree Antequera, Jose Javier Aguirre, Belén González-Lahera, Alicia Maroto, and Ana B. Pastor for their helpful support and technical assistance. The authors want to particularly acknowledge the patients enrolled in this study for their participation and the Biobanco imas12 in Hospital 12 de Octubre integrated in the in Spanish Hospital Biobanks Network (RetBioH; www.redbiobancos.es). Biobank is supported by Instituto de Salud Carlos III. This work was supported by a grant from GEROA Diagnostics (grant 2015/82).es_ES
dc.language.isoenges_ES
dc.publisherElsevier es_ES
dc.type.hasVersionAMes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshDiagnosis es_ES
dc.subject.meshDementia es_ES
dc.subject.meshMild cognitive impairmentes_ES
dc.subject.meshAlzheimer’s diseasees_ES
dc.subject.meshLactoferrin es_ES
dc.subject.meshSaliva es_ES
dc.subject.meshNoninvasive biomarkeres_ES
dc.titleEarly diagnosis of mild cognitive impairment and Alzheimer's disease based on salivary lactoferrin.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID28649597es_ES
dc.format.volume8es_ES
dc.format.number1es_ES
dc.format.page131-138es_ES
dc.identifier.doi10.1016/j.dadm.2017.04.002es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2352-8729es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.dadm.2017.04.002es_ES
dc.identifier.journalAlzheimer's & dementia (Amsterdam, Netherlands)es_ES
dc.repisalud.centroISCIII::Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC)es_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/2015/82es_ES
dc.rights.accessRightsopen accesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 Internacional