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dc.contributor.authorLópez, Daniel 
dc.contributor.authorLorente, Elena 
dc.contributor.authorBarriga, Alejandro 
dc.contributor.authorJohnstone, Carolina 
dc.contributor.authorMir-Gerrero, Carmen 
dc.date.accessioned2020-06-24T07:19:02Z
dc.date.available2020-06-24T07:19:02Z
dc.date.issued2013-09
dc.identifier.citationExpert Rev Vaccines . 2013 Sep;12(9):1077-83es_ES
dc.identifier.issn1476-0584es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10548
dc.description.abstractThe cytotoxic CD8(+) T lymphocyte-mediated cellular response is important for the elimination of virus-infected cells and requires the prior recognition of short viral peptide antigens previously translocated to the endoplasmic reticulum by the transporter associated with antigen processing (TAP). However, individuals with nonfunctional TAP complexes or infected cells with TAP molecules blocked by specific viral proteins, such as the cowpoxvirus, a component of the first source of early empirical vaccination against smallpox, are still able to present several HLA class I ligands generated by the TAP-independent antigen processing pathways to specific cytotoxic CD8(+) T lymphocytes. Currently, bioterrorism and emerging infectious diseases have renewed interest in poxviruses. Recent works that have identified HLA class I ligands and epitopes in virus-infected TAP-deficient cells have implications for the study of both the effectiveness of early empirical vaccination and the analysis of HLA class I antigen processing in TAP-deficient subjects.es_ES
dc.description.sponsorshipThis work was supported by a grant provided by the ‘Ministerio de Ciencia e Innovación’ and this funding agency had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.es_ES
dc.language.isoenges_ES
dc.publisherTaylor & Francis es_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAntigen Presentation es_ES
dc.subject.meshMetabolic Networks and Pathways es_ES
dc.subject.meshATP-Binding Cassette Transporters es_ES
dc.subject.meshCD8-Positive T-Lymphocytes es_ES
dc.subject.meshEpitopes, T-Lymphocyte es_ES
dc.subject.meshHistocompatibility Antigens Class I es_ES
dc.subject.meshHumans es_ES
dc.subject.meshSmallpox Vaccine es_ES
dc.subject.meshVaccination es_ES
dc.titleVaccination and the TAP-independent antigen processing pathways.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID24053400es_ES
dc.format.volume12es_ES
dc.format.number9es_ES
dc.format.page1077-83es_ES
dc.identifier.doi10.1586/14760584.2013.825447es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)
dc.description.peerreviewedes_ES
dc.identifier.e-issn1744-8395es_ES
dc.relation.publisherversionhttps://doi.org/10.1586/14760584.2013.825447es_ES
dc.identifier.journalExpert review of vaccineses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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