Show simple item record

dc.contributor.authorSerrano, Antonio L
dc.contributor.authorMunoz-Canoves, Pura 
dc.date.accessioned2020-06-18T13:30:22Z
dc.date.available2020-06-18T13:30:22Z
dc.date.issued2017-04
dc.identifier.citationSemin Cell Dev Biol. 2017; 64:181-190es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10494
dc.description.abstractDuchenne muscular dystrophy (DMD) is one of the most devastating neuromuscular genetic diseases caused by the absence of dystrophin. The continuous episodes of muscle degeneration and regeneration in dystrophic muscle are accompanied by chronic inflammation and fibrosis deposition, which exacerbate disease progression. Thus, in addition of investigating strategies to cure the primary defect by gene/cell therapeutic strategies, increasing efforts are being placed on identifying the causes of the substitution of muscle by non-functional fibrotic tissue in DMD, aiming to attenuate its severity. Congenital muscular dystrophies (CMDs) are early-onset diseases in which muscle fibrosis is also present. Here we review the emerging findings on the mechanisms that underlie fibrogenesis in muscular dystrophies, and potential anti-fibrotic treatments.es_ES
dc.description.sponsorshipWork in the authors laboratory has been funded by ISCIII, Spain (FIS-P509/01267, FIS-PI13/02512) and MINECO (SAF2015-67369R; "Maria de Maeztu" Programme for Units of Excellence in R&D MDM-2014-0370), AFM, E-Rare/ERANET, Fundacio Marato TV3, MDA and DPP-Spain.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshTranslational Medical Research es_ES
dc.subject.meshAge of Onset es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshFibrosis es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMacrophages es_ES
dc.subject.meshModels, Biologicales_ES
dc.subject.meshMuscular Dystrophies es_ES
dc.titleFibrosis development in early-onset muscular dystrophies: Mechanisms and translational implications.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID27670721es_ES
dc.format.volume64es_ES
dc.format.page181-190es_ES
dc.identifier.doi10.1016/j.semcdb.2016.09.013es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIII
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España)
dc.contributor.funderFundació La Marató
dc.description.peerreviewedes_ES
dc.identifier.e-issn1096-3634es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.semcdb.2016.09.013es_ES
dc.identifier.journalSeminars in cell & developmental biologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio de Regeneración Tisulares_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/P509/01267es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI13/02512es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-67369Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MDM-2014-0370es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


Files in this item

Acceso Abierto
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional