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dc.contributor.authorGarcía-Prat, Laura
dc.contributor.authorMunoz-Canoves, Pura 
dc.date.accessioned2020-06-18T11:32:14Z
dc.date.available2020-06-18T11:32:14Z
dc.date.issued2017-04
dc.identifier.citationMol Cell Endocrinol. 2017; 445:109-117es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10493
dc.description.abstractAll tissues and organs undergo a progressive regenerative decline as they age. This decline has been mainly attributed to loss of stem cell number and/or function, and both stem cell-intrinsic changes and alterations in local niches and/or systemic environment over time are known to contribute to the stem cell aging phenotype. Advancing in the molecular understanding of the deterioration of stem cell cells with aging is key for targeting the specific causes of tissue regenerative dysfunction at advanced stages of life. Here, we revise exciting recent findings on why stem cells age and the consequences on tissue regeneration, with a special focus on regeneration of skeletal muscle. We also highlight newly identified common molecular pathways affecting diverse types of aging stem cells, such as altered proteostasis, metabolism, or senescence entry, and discuss the questions raised by these findings. Finally, we comment on emerging stem cell rejuvenation strategies, principally emanating from studies on muscle stem cells, which will surely burst tissue regeneration research for future benefit of the increasing human aging population.es_ES
dc.description.sponsorshipWork in the authors' laboratories was supported by SAF201567369-R (MINECO, Spain), Convenio UPF-CNIC, AFM, E-Rare/Eranet, MDA, Fundacio Marato-TV3, DPP-NLes_ES
dc.language.isoenges_ES
dc.publisherElsevier es_ES
dc.type.hasVersionAMes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshAging es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshCellular Senescence es_ES
dc.subject.meshDNA Damage es_ES
dc.subject.meshEnergy Metabolism es_ES
dc.subject.meshEpigenesis, Genetic es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMuscle, Skeletal es_ES
dc.subject.meshRegeneration es_ES
dc.subject.meshSignal Transduction es_ES
dc.subject.meshStem Cells es_ES
dc.titleAging, metabolism and stem cells: Spotlight on muscle stem cells.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID27531569es_ES
dc.format.volume445es_ES
dc.format.page109-117es_ES
dc.identifier.doi10.1016/j.mce.2016.08.021es_ES
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España) 
dc.contributor.funderPompeu Fabra University (España) 
dc.contributor.funderCentro Nacional de Investigaciones Cardiovasculares Carlos III (España) 
dc.contributor.funderFundación La Marató TV3 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1872-8057es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.mce.2016.08.021es_ES
dc.identifier.journalMolecular and cellular endocrinologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio de Regeneración Tisulares_ES
dc.repisalud.institucionCNICes_ES
dc.rights.accessRightsopen accesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 Internacional