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dc.contributor.authorPodlesnikar, Tomaž
dc.contributor.authorPizarro, Gonzalo 
dc.contributor.authorFernandez-Jimenez, Rodrigo 
dc.contributor.authorMontero-Cabezas, Jose M
dc.contributor.authorGreif, Nina
dc.contributor.authorSanchez-Gonzalez, Javier 
dc.contributor.authorBucciarelli-Ducci, Chiara
dc.contributor.authorMarsan, Nina Ajmone
dc.contributor.authorFras, Zlatko
dc.contributor.authorBax, Jeroen J
dc.contributor.authorFuster, Valentin 
dc.contributor.authorIbanez, Borja 
dc.contributor.authorDelgado, Victoria
dc.identifier.citationJ Cardiovasc Magn Reson. 2020; 22(1):44es_ES
dc.description.abstractWe aimed to evaluate the effect of early intravenous metoprolol treatment, microvascular obstruction (MVO), intramyocardial hemorrhage (IMH) and adverse left ventricular (LV) remodeling on the evolution of infarct and remote zone circumferential strain after acute anterior ST-segment elevation myocardial infarction (STEMI) with feature-tracking cardiovascular magnetic resonance (CMR). A total of 191 patients with acute anterior STEMI enrolled in the METOCARD-CNIC randomized clinical trial were evaluated. LV infarct zone and remote zone circumferential strain were measured with feature-tracking CMR at 1 week and 6 months after STEMI. In the overall population, the infarct zone circumferential strain significantly improved from 1 week to 6 months after STEMI (- 8.6 ± 9.0% to - 14.5 ± 8.0%; P < 0.001), while no changes in the remote zone strain were observed (- 19.5 ± 5.9% to - 19.2 ± 3.9%; P = 0.466). Patients who received early intravenous metoprolol had significantly more preserved infarct zone circumferential strain compared to the controls at 1 week (P = 0.038) and at 6 months (P = 0.033) after STEMI, while no differences in remote zone strain were observed. The infarct zone circumferential strain was significantly impaired in patients with MVO and IMH compared to those without (P < 0.001 at 1 week and 6 months), however it improved between both time points regardless of the presence of MVO or IMH (P < 0.001). In patients who developed adverse LV remodeling (defined as ≥ 20% increase in LV end-diastolic volume) remote zone circumferential strain worsened between 1 week and 6 months after STEMI (P = 0.036), while in the absence of adverse LV remodeling no significant changes in remote zone strain were observed. Regional LV circumferential strain with feature-tracking CMR allowed comprehensive evaluation of the sequelae of an acute STEMI treated with primary percutaneous coronary intervention and demonstrated long-lasting cardioprotective effects of early intravenous metoprolol., NCT01311700. Registered 8 March 2011 - Retrospectively registered.es_ES
dc.description.sponsorshipMETOCARD-CNIC trial work was partially supported by the Centro Nacional de Investigaciones Cardiovasculares (CNIC), through CNIC Translational Grant 01–2009. Other sponsors were the Spanish Ministry of Health and Social Policy (EC10–042), the Mutua Madrileña Foundation (AP8695–2011), and a Master Research Agreement (MRA) between Philips healthcare and the CNIC. BI is recipient of the ISCIII Fondo de Investigación Sanitaria grants and ERDF/FEDER funds (PI16/02110, DTS17/00136, PI13/01979, SAF2015–71613-REDI) related to this topic. The CNIC is supported by the Ministerio de Ciencia, Innovación y Universidades (MICINN) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). CBD is supported by the Bristol National Institute of Health Research (NIHR)Biomedical Research Centre (BRC). The views expressed are those of the authors and not necessarily those of the National Health Service, NIHR or Department of Health. The department of Cardiology of the Leiden University Medical Center received unrestricted research grants from Biotronik, Medtronic, Boston Scientific and Edwards Lifesciences.es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.titleLeft ventricular functional recovery of infarcted and remote myocardium after ST-segment elevation myocardial infarction (METOCARD-CNIC randomized clinical trial substudy).es_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderCentro Nacional de Investigaciones Cardiovasculares (CNIC)es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderFundación ProCNICes_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderNational Institute of Health Reseach (Reino Unido)es_ES
dc.identifier.journalJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonancees_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovasculares_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionaleses_ES

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